Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Antimorphic

Synonym(s): negative dominant

Antimorphic is a dominant loss-of-function mutation. It is common with homo-dimers and some -multimers when the mutated protein negatively affects the function of the protein complex, so also the normal protein becomes ineffective and cannot compensate the loss of function.

Related terms:

Glossterms object (57) Glossterms object (58) Glossterms object (65) Glossterms object (67)