Arteriosclerosis is a vascular disease in the arterial system that causes many organ disorders including myocardial infarction, cerebral infarction etc.
There are lot of investigation developed that allow us to determine localization and extention of arteriosclerotic lesions. But to clarify the pathogenesis only risk factors can be established.
The pathogenesis is not fully understood. There are several risk factors known until now: these include environmantal factors (smoking, diet), thrombotic and lipid disorders.
|Hereditary vascular disease|
|Generalized arterial calcification of infancy|
Lusis AJ et al. (2004) Genetic basis of atherosclerosis: part I: new genes and pathways.[^]
Hingorani AD et al. (1999) A common variant of the endothelial nitric oxide synthase (Glu298-->Asp) is a major risk factor for coronary artery disease in the UK.[^]
Kluijtmans LA et al. (1996) Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.[^]