Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Arteriosclerosis

Arteriosclerosis is a vascular disease in the arterial system that causes many organ disorders including myocardial infarction, cerebral infarction etc.

Test Strategy

There are lot of investigation developed that allow us to determine localization and extention of arteriosclerotic lesions. But to clarify the pathogenesis only risk factors can be established.

Pathogenesis

The pathogenesis is not fully understood. There are several risk factors known until now: these include environmantal factors (smoking, diet), thrombotic and lipid disorders.

Systematic

Hereditary vascular disease
Arteriosclerosis
APOB
APOE
HABP2
LDLR
LPA
MTHFR
PON1
SLC3A1
Diabetic microangiopathy 4
Generalized arterial calcification of infancy
Hereditary Angioedema
Hereditary lymphedema
STING-associated vasculopathy with onset in infancy
Sneddon syndrome
Susceptibility to arteriovenous malformations of the brain
Thromboembolic diseases
Vasculitis due to ADA2 deficiency

References:

1.

Lusis AJ et al. (2004) Genetic basis of atherosclerosis: part I: new genes and pathways.

[^]
2.

Kluijtmans LA et al. (1996) Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

[^]
3.

Hingorani AD et al. (1999) A common variant of the endothelial nitric oxide synthase (Glu298-->Asp) is a major risk factor for coronary artery disease in the UK.

[^]
4.

OMIM.ORG article

Omim 208060 [^]
5.

Wikipedia article

Wikipedia EN (Arteriosclerosis) [^]
Update: April 29, 2019