Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

MODY diabetes

MODY diabetes is the autosomal dominant form of type 2 diabetes.

Test Strategy

The following criteria are essential for the diagnosis of MODY diabetes:1. juvenile onset of diabetes.2. primarily no insulin dependency.3. autosomal dominant inheritance.4. confirmation by molecular test.

Pathogenesis

Genes controlling insulin secretion are responsible for this kind of diabetes. Which way also insulin sensitivity is diminished is not clear yet.

Systematic

Diabetes mellitus
Autoimmune diabetes
Diabetic nephropathy
Diabetic retinopathy
Gestational diabetes mellitus
Hereditary susceptibility to diabetes
Insulin resistance
MODY diabetes
MODY1 diabetes
HNF4A
MODY10 diabetes
INS
MODY11 diabetes
BLK
MODY12 diabetes
ABCC8
MODY13 diabetes
KCNJ11
MODY14 diabetes
APPL1
MODY2 diabetes
GCK
MODY3 diabetes
HNF1A
MODY4 diabetes
PDX1
MODY5 diabetes
HNF1B
MODY6 diabetes
NEUROD1
MODY7 diabetes
KLF11
MODY8 diabetes
CEL
MODY9 diabetes
PAX4
Mitochondrial diabetes
Neonatal diabetes mellitus
Noninsulin-dependent diabetes mellitus 1
Pancreatogenic diabetes
Severe obesity and type 2 diabetes

References:

1.

Fajans SS et al. (2001) Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.

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2.

Weng J et al. (2002) Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus.

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Update: Sept. 26, 2018