Hereditary complement disorders
Hereditary disturbances of the complemet system includes dysfunction of proteins that form the complex regulatory system. Dysfunctions may result in impaired defense against infections or autoaggresive reactions.
Lipsker D et al. (2010) Cutaneous manifestations of complement deficiencies.[^]
Mayilyan KR et al. (2012) Complement genetics, deficiencies, and disease associations.[^]
Laursen NS et al. (2012) Structure, function and control of complement C5 and its proteolytic fragments.[^]
de Cordoba SR et al. (2012) Complement dysregulation and disease: from genes and proteins to diagnostics and drugs.[^]
Tichaczek-Goska D et al. () Deficiencies and excessive human complement system activation in disorders of multifarious etiology.[^]
Grumach AS et al. (2014) Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach.[^]