Pregnancy exacerbated hypertension
A mutation of the mineralocorticoid receptor causes increased sensity for aldosterone and also progesterone. Thus women during pregnancy or administration of progesterone-containing contraceptives will develop severe hypertension. Only one mutation (p.S810L) is described so far to have this effect. Inheritance is autosomal dominant.
|Apparent mineralocorticoid excess|
|Pregnancy exacerbated hypertension|
Geller DS et al. (2000) Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy.[^]