Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Apolipoprotein deficiency

Apolipoprotein deficiencies are defined as deficiencies in certain protein components of lipoprotein. Because of the various functions of these proteins deficiencies may or may not result in disturbances of various pathophysiological pathways. This may include but is not restricted to dyslipidemias as also coagulation, immune response, tumor and even neuronal degeneration and aging may be influenced.

Diagnosis

As there is a lot of redundancy and overlapping in apolipoprotein function the interpretation of abnormalities usually requires to consider all apolipoproteins simultaneously.

Systematic

Dyslipidemia
Apolipoprotein deficiency
APOA5
APOB
APOC1
APOC2
APOC3
APOE
APOL1
APOM
Apolipoprotein A1 deficiency
APOA1
Apolipoprotein A2 deficiency
APOA2
Apolipoprotein F deficiency
APOF
Apolipoprotein H deficiency
APOH
CLU
Betalipoprotein deficiency
Epigenetic dyslipidemia
Hyperalphalipoproteinemia 1
Hyperalphalipoproteinemia 2
Hyperlipemia
Hypoalphalipoproteinemia
Hypobetalipoproteinemia

References:

1.

Wang QF et al. (2004) Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons.

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Update: Sept. 26, 2018