Trehalase deficiency is an autosomal dominant disorder caused by mutations of the TREH gene. Gastrointestinal symptoms can manifest after the ingestion of a larger amount of young edible mushrooms. In older mushrooms trehalose is cleaved into glucose and the symptoms does not appear.
Diarrhea in patients with trehalase deficiency manifests after the ingestion of greater amounts of trehalase, predominantly in young mushrooms.
Welsh JD et al. (1978) Intestinal disaccharidase activities in relation to age, race, and mucosal damage.[^]
Murray IA et al. (2000) Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease.[^]
Gudmand-Høyer E et al. (1988) Trehalase deficiency in Greenland.[^]