Trehalase deficiency is an autosomal dominant disorder caused by mutations of the TREH gene. Gastrointestinal symptoms can manifest after the ingestion of a larger amount of young edible mushrooms. In older mushrooms trehalose is cleaved into glucose and the symptoms does not appear.
Diarrhea | |
Diarrhea in patients with trehalase deficiency manifests after the ingestion of greater amounts of trehalase, predominantly in young mushrooms. |
1. |
Welsh JD et al. (1978) Intestinal disaccharidase activities in relation to age, race, and mucosal damage. |
2. |
Murray IA et al. (2000) Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease. |
3. |
Gudmand-Høyer E et al. (1988) Trehalase deficiency in Greenland. |
4. |
OMIM.ORG article Omim 612119 |
5. |
Orphanet article Orphanet ID 103909 |