Fructose malabsorption is a food intolerance based on mutations of the SLC2A5 gene. If fructose is not absorbed by the intestinal brush border cells osmotic diarrhea results which can lead to chronic inflammation and morphological alterations.
The ingestion of large amounts of fructose may induce diarrhea in patients with fructose malabsorption.
Davidson NO et al. (1992) Human intestinal glucose transporter expression and localization of GLUT5.[^]
Burant CF et al. (1992) Fructose transporter in human spermatozoa and small intestine is GLUT5.[^]
Kayano T et al. (1990) Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).[^]
Jones HF et al. (2011) Intestinal fructose transport and malabsorption in humans.[^]
White PS et al. (1998) Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2.[^]
OMIM.ORG articleOmim 138230 [^]
Wikipedia articleWikipedia EN (Fructose_malabsorption) [^]