Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Fructose malabsorption

Fructose malabsorption is a food intolerance based on mutations of the SLC2A5 gene. If fructose is not absorbed by the intestinal brush border cells osmotic diarrhea results which can lead to chronic inflammation and morphological alterations.

Symptoms

Diarrhea
The ingestion of large amounts of fructose may induce diarrhea in patients with fructose malabsorption.

Systematic

Food intolerance
Adult type lactose intolerance
Eosinophil peroxidase deficiency
Fructose intolerance
Fructose malabsorption
SLC2A5
Fructose-1,6-bisphosphatase deficiency
Fructosuria
Glucose-Galactose Malabsorption
Histamine Intolerance
Lactase deficiency
Lysinuric protein intolerance
Mast cell activation syndrome
Sitosterolemia
Trehalase deficiency

References:

1.

Davidson NO et al. (1992) Human intestinal glucose transporter expression and localization of GLUT5.

[^]
2.

Burant CF et al. (1992) Fructose transporter in human spermatozoa and small intestine is GLUT5.

[^]
3.

Kayano T et al. (1990) Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).

[^]
4.

Jones HF et al. (2011) Intestinal fructose transport and malabsorption in humans.

[^]
5.

White PS et al. (1998) Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2.

[^]
Update: Sept. 26, 2018