Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Poor response to Eculizumab

Despite its great efficiency some patient do not properly respond to eculizumab. This poor response it mostly due to genetic variations in the complement C5 gene, but also other complement genes can be affected theoretically.


Thrombotic microangiopathies
Hemolytic-Uremic Syndrome
Poor response to Eculizumab
Thrombotic Thrombocytopenic Purpura



Nishimura J et. al. (2014) Genetic variants in C5 and poor response to eculizumab.

Update: Sept. 26, 2018