Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Complement C8 deficiency type 1

>Complement C8 deficiency type 1 is the deficiency of the alpha subunit of the protein. Clinically, there is no distinction between type 1 and type 2 (related to beta subunit). Both types predispose to meningococcal infections.


Complement C8 deficiency
Complement C8 deficiency type 1
Complement C8 deficiency type 2



Kojima T et al. (1998) Genetic basis of human complement C8 alpha-gamma deficiency.


Ross SC et al. (1984) Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency.


Fukumori Y et. al. (1998) Terminal complement component deficiencies in Japan.


Petersen BH et al. (1976) Human deficiency of the eighth component of complement. The requirement of C8 for serum Neisseria gonorrhoeae bactericidal activity.


Jasin HE et al. (1977) Absence of the eighth component of complement in association with systemic lupus erythematosus-like disease.


Tedesco F et al. (1990) Two distinct abnormalities in patients with C8 alpha-gamma deficiency. Low level of C8 beta chain and presence of dysfunctional C8 alpha-gamma subunit.


Matthews N et al. (1980) Recurrent meningococcal infections associated with a functional deficiency of the C8 component of human complement.


Tedesco F et al. (1983) Two types of dysfunctional eighth component of complement (C8) molecules in C8 deficiency in man. Reconstitution of normal C8 from the mixture of two abnormal C8 molecules.


Pickering RJ et al. (1982) Identification of the alpha-gamma subunit of the eighth component of complement (C8) in a patient with systemic lupus erythematosus and absent C8 activity: patients and family studies.

Update: Sept. 26, 2018