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Meningococcal infection susceptibility

The genetic predisposition to to meningococcal meningitis is defined by complement deficiencies in particular of the terminal membrane attack complex (C5-C9). Also complement regulatory protein can be altered, C3, CFH, CFD, and CFP for instance.

Management

Prophylaxis is successful with vaccination.

Systematic

Disposition to infections
Disorders of mRNA editing
Familial candidiasis
Genetic susceptibility to aspergillosis
HIV resistance
IRAK4 deficiency
Invasive pneumococcal disease
Measles infection susceptibility
Meningococcal infection susceptibility
C3
C5
C7
C8A
C8B
C8G
C9
CD46
CFB
CFD
CFH
CFP
Resistance to trypanosoma brucei
Septic shock
Susceptibility to bacteremia 1
Susceptibility to malaria
Susceptibility to mycobacterial diseases
Susceptibility to pseudomonas infection
X-linked mendelian susceptibility to mycobacterial diseases due to IKBKG deficiency

References:

1.

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3.

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10.

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11.

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12.

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18.

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29.

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32.

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39.

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40.

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41.

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42.

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43.

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44.

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45.

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46.

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47.

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48.

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49.

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50.

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51.

Lee TJ et al. (1978) Familial deficiency of the seventh component of complement associated with recurrent bacteremic infections due to Neisseria.

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52.

Petersen BH et al. (1979) Neisseria meningitidis and Neisseria gonorrhoeae bacteremia associated with C6, C7, or C8 deficiency.

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53.

Rittner C et al. (1976) Lack of linkage between gene(s) controlling the synthesis of the seventh component of complement and the HLA region on chromosome No. 6 in man.

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54.

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55.

OMIM.ORG article

Omim 312060 external link
Update: Aug. 14, 2020
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