Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Glucocorticoid triggered hypertension

Various genetic alterations at the glucocorticoid receptor locus can trigger hight blood pressure. Among them the most severe form, the glucocorticoid resistance, which is associated with hyperaldosteronism, and also various polymorphisms can contribute to hypertension in metabolic syndrome and endocrinological disorders.

Systematic

Monogenic hypertension
Apparent mineralocorticoid excess
Glucocorticoid triggered hypertension
NR3C1
Hyperaldosteronism
Hypertension and brachydactyly syndrome
Liddle syndrome
Pseudohypoaldosteronism

References:

1.

Nicolaides NC et. al. (2015) Chrousos syndrome: from molecular pathogenesis to therapeutic management.

[^]
2.

Lin S et. al. (2014) Interaction between occupational stress and GR gene polymorphisms on essential hypertension among railway workers.

[^]
3.

Moreira RP et. al. (2013) Modulatory effect of BclI GR gene polymorphisms on the obesity phenotype in Brazilian patients with Cushing's disease.

[^]
4.

Islam A et. al. (2012) Glucocorticoid receptor density correlates with health risk factors and insulin resistance in Caucasian and African American subjects.

[^]
Update: Sept. 26, 2018