Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Statin intolerance

Statin intolerance is characterized by muscular pain that arise a couple of days after the nitiation of a lipid lowering therapy. In most severe cases, it can develop into rhabdomyolysis, renal insufficiency, and death. Inadequate hepatic metabolism of the medicament is the cause which leads to accumulation in muscle cells. Genetically a mutation in genes encoding enzymes and transporters involved in statin metabolism..

Systematic

Hereditary lipid disorders
Attenuated cholesterol lowering by statins
Disorders of mRNA editing
Disturbances of body fat distribution
Disturbed regulators of lipid and carbohydrate metabolism
Dyslipidemia
Hepatic CPT-deficiency type 1A
Neutral lipid storage disease
Sea-blue histiocyte disease
Statin intolerance
SLCO1B1
Tangier Disease

References:

1.

van de Steeg E et al. (2012) Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.

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2.

Wolkoff AW et al. (1976) Rotor's syndrome. A distinct inheritable pathophysiologic entity.

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3.

Wolpert E et al. (1977) Abnormal sulfobromophthalein metabolism in Rotor's syndrome and obligate heterozygotes.

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4.

Dollinger MR et al. (1967) Chronic familial hyperbilirubinemia. Hepatic defect(s) associated with occult hemolysis.

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5.

SCHIFF L et al. (1959) Familial nonhemolytic jaundice with conjugated bilirubin in the serum; a case study.

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Update: April 29, 2019