The disposition to develop gout disease is hereditary. For type 1, the gene ABCG2 is responsible.
Hyperuricemia | ||||
Gout susceptibility 1 | ||||
ABCG2 | ||||
Hyperuricemic nephropathy | ||||
Kelley-Seegmiller syndrome | ||||
Lesch-Nyhan syndrome | ||||
1. |
Dehghan A et al. (2008) Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. |
2. |
Matsuo H et al. (2009) Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population. |
3. |
Martinon F et al. (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. |
4. |
None (1979) Genetics of hyperuricemia in families with gout. |
5. |
Healey LA et al. (1967) Hyperuricemia in Filipinos: interaction of heredity and environment. |
6. |
HAUGE M et al. (1955) Heredity in gout and hyperuricemia. |
7. |
None (1960) Heredity in primary gout. |
8. |
NEEL JV et al. (1965) STUDIES ON HYPERURICEMIA. II. A RECONSIDERATION OF THE DISTRIBUTION OF SERUM URIC ACID VALUES IN THE FAMILIES OF SMYTH, COTTERMAN, AND FREYBERG. |
9. |
Cheng LS et al. (2004) Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25. |
10. |
Woodward OM et al. (2011) ABCG transporters and disease. |
11. |
Köttgen A et al. (2013) Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. |
12. |
OMIM.ORG article Omim 138900 |