Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Gout susceptibility 1

The disposition to develop gout disease is hereditary. For type 1, the gene ABCG2 is responsible.

Systematic

Hyperuricemia
Gout susceptibility 1
ABCG2
Hyperuricemic nephropathy
Kelley-Seegmiller syndrome
Lesch-Nyhan syndrome

References:

1.

Dehghan A et al. (2008) Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.

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2.

Matsuo H et al. (2009) Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.

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3.

Martinon F et al. (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome.

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4.

None (1979) Genetics of hyperuricemia in families with gout.

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5.

Healey LA et al. (1967) Hyperuricemia in Filipinos: interaction of heredity and environment.

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6.

HAUGE M et al. (1955) Heredity in gout and hyperuricemia.

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7.

None (1960) Heredity in primary gout.

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8.

NEEL JV et al. (1965) STUDIES ON HYPERURICEMIA. II. A RECONSIDERATION OF THE DISTRIBUTION OF SERUM URIC ACID VALUES IN THE FAMILIES OF SMYTH, COTTERMAN, AND FREYBERG.

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9.

Cheng LS et al. (2004) Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25.

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10.

Woodward OM et al. (2011) ABCG transporters and disease.

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11.

Köttgen A et al. (2013) Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

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12.

OMIM.ORG article

Omim 138900 [^]
Update: April 29, 2019