Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Failure of tooth eruption

Failure of tooth eruption is an autosomal dominant disorder caused by mutations of the PTHR1 gene. Patients present with various dentification problems. The failure of tooth eruption often leads to asymmetric hypodontia.

Systematic

Bone dysplasia
Achondroplasia
Achondroplasia-SCID syndrome
Acrocapitofemoral dysplasia
Antley-Bixler syndrome 1
Antley-Bixler syndrome 2
Apert syndrome
Cherubism
Chondrodysplasia of Blomstrand type
Chondrodysplasia, Grebe type
Crouzon syndrome
Eiken syndrome
Failure of tooth eruption
PTH1R
McCune-Albright syndrom
Metaphyseal chondrodysplasia of Murk Jansen type
Muenke syndrome
Osteofibrous dysplasia
Osteopathia striata with cranial sclerosis
Schimke Immunoosseous dysplasia
Thanatophoric dysplasia 1
Thanatophoric dysplasia 2

References:

1.

Decker E et al. (2008) PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption.

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2.

Bosker H et al. (1978) Familial reinclusion of permanent molars.

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3.

Bianchi SD et al. (1991) Primary impaction of primary teeth: a review and report of three cases.

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4.

None (1974) Complete failure of eruption of all permanent teeth: an autosomal dominant disorder.

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5.

Proffit WR et al. (1981) Primary failure of eruption: a possible cause of posterior open-bite.

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6.

O'Connell AC et al. (1999) Primary failure of tooth eruption: a unique case.

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7.

Dibiase AT et al. (2000) Primary failure of eruption in the permanent dentition of siblings.

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8.

Ahmad S et al. (2006) The clinical features and aetiological basis of primary eruption failure.

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9.

Frazier-Bowers SA et al. (2007) Primary failure of eruption: further characterization of a rare eruption disorder.

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10.

OMIM.ORG article

Omim 125350 [^]
Update: April 29, 2019