Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Humoral hypercalcemia of malignancy

Humoral hypercalcemia of malignancy is a paraneoplastic symptom that is caused by an enhanced secretion of PTH-related protein. It is not clear yet if structural variations of the PTHLH gene influence the paraneoplastic response.

Systematic

Disorders of the parathyroid hormone system
Humoral hypercalcemia of malignancy
PTHLH
Hyperparathyroidism
Hypoparathyroidism
Parathyroid carcinoma
Pseudohyperparathyreoidism
Pseudohypoparathyroidism

References:

1.

Lanske B et al. (1996) PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.

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2.

Maass PG et al. (2010) A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E.

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3.

Klopocki E et al. (2010) Deletion and point mutations of PTHLH cause brachydactyly type E.

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4.

Wysolmerski JJ et al. (2001) Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein receptors in humans is associated with abnormal breast development and tooth impaction.

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5.

Hendy GN et al. (1990) Gene for parathyroid hormone-like peptide is on mouse chromosome 6.

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6.

Hammonds RG et al. (1989) Purification and characterization of recombinant human parathyroid hormone-related protein.

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7.

Yasuda T et al. (1989) Characterization of the human parathyroid hormone-like peptide gene. Functional and evolutionary aspects.

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8.

Mangin M et al. (1988) Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy.

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9.

Moseley JM et al. (1987) Parathyroid hormone-related protein purified from a human lung cancer cell line.

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10.

Mangin M et al. (1989) Isolation and characterization of the human parathyroid hormone-like peptide gene.

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11.

Broadus AE et al. (1988) Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide.

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12.

Suva LJ et al. (1987) A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression.

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13.

Holick MF et al. (1994) A parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice.

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14.

Karaplis AC et al. (1994) Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

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15.

Vortkamp A et al. (1996) Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.

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16.

Henry JG et al. (1997) Parathyroid hormone-related protein-(1-36) is biologically active when administered subcutaneously to humans.

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17.

Wysolmerski JJ et al. (1998) Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.

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18.

Philbrick WM et al. (1998) Parathyroid hormone-related protein is required for tooth eruption.

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19.

Lanske B et al. (1999) Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.

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20.

None (2000) The physiology of parathyroid hormone-related protein.

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21.

Manenti G et al. (2000) A cancer modifier role for parathyroid hormone-related protein.

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22.

Miao D et al. (2002) Parathyroid hormone is essential for normal fetal bone formation.

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23.

Bakre MM et al. (2002) Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor.

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24.

Hsiao LT et al. (2002) Superior vena cava syndrome and hypercalcaemia in a patient with a primary mediastinal B-cell lymphoma secreting parathyroid hormone-related protein.

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25.

None (2003) 10 years of mouse cancer modifier loci: human relevance.

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26.

Kir S et al. (2014) Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.

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27.

OMIM.ORG article

Omim 168470 [^]
Update: April 29, 2019