Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Body mass index quantitative trait

The group includes all genetic loci that can effect body stature as measured by the body mass index (BMI).

Systematic

Obesity
Autosomal dominant obesity
Body mass index quantitative trait
BMI effecting trait 14
FTO
Early-onset obesity
Late-onset obesity
Severe obesity
Severe obesity and type 2 diabetes
Susceptibility to obesity

References:

1.

Meyre D et. al. (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

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2.

Masud S et. al. (2003) Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis.

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3.

Hallstrand TS et. al. (2005) Genetic pleiotropy between asthma and obesity in a community-based sample of twins.

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4.

Hanson RL et al. (1998) An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians.

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5.

Deeb SS et. al. (1998) A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.

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6.

Rice T et. al. (1999) Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Québec family study.

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7.

Valve R et. al. (1999) Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women.

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8.

Hsueh WC et. al. (2001) Genome-wide scan of obesity in the Old Order Amish.

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9.

Feitosa MF et. al. (2002) Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: the National Heart, Lung, and Blood Institute Family Heart Study.

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10.

Atwood LD et. al. (2002) Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study.

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11.

Platte P et. al. (2003) A study of linkage and association of body mass index in the Old Order Amish.

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12.

Yanagiya T et. al. (2007) Association of single-nucleotide polymorphisms in MTMR9 gene with obesity.

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13.

Walley AJ et. al. (2009) The genetic contribution to non-syndromic human obesity.

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14.

Speliotes EK et. al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

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15.

Kilpeläinen TO et. al. (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

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16.

Shungin D et. al. (2015) New genetic loci link adipose and insulin biology to body fat distribution.

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17.

Locke AE et. al. (2015) Genetic studies of body mass index yield new insights for obesity biology.

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Update: Sept. 26, 2018