Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Noninsulin-dependent diabetes mellitus 1

Noninsulin-dependent diabetes mellitus can be caused by various gene mutations. The disease caused by CAPN10 mutations is a separate subgroup.


Diabetes mellitus
Autoimmune diabetes
Diabetic nephropathy
Diabetic retinopathy
Gestational diabetes mellitus
Hereditary susceptibility to diabetes
Insulin resistance
MODY diabetes
Mitochondrial diabetes
Neonatal diabetes mellitus
Noninsulin-dependent diabetes mellitus 1
Pancreatogenic diabetes
Severe obesity and type 2 diabetes



Hanis CL et. al. (1996) A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.


Altshuler D et. al. (2000) Guilt by association.


Horikawa Y et. al. (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.


None (2001) Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene.


Kang ES et. al. (2006) A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes.


Ghosh S et. al. (1998) A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.


Cox NJ et. al. (1999) Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans.


Busfield F et. al. (2002) A genomewide search for type 2 diabetes-susceptibility genes in indigenous Australians.

Update: Sept. 26, 2018