Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Noninsulin-dependent diabetes mellitus 1

Noninsulin-dependent diabetes mellitus can be caused by various gene mutations. The disease caused by CAPN10 mutations is a separate subgroup.

Systematic

Diabetes mellitus
Autoimmune diabetes
Diabetic nephropathy
Diabetic retinopathy
Gestational diabetes mellitus
Hereditary susceptibility to diabetes
Insulin resistance
MODY diabetes
Mitochondrial diabetes
Neonatal diabetes mellitus
Noninsulin-dependent diabetes mellitus 1
CAPN10
Pancreatogenic diabetes
Severe obesity and type 2 diabetes

References:

1.

Hanis CL et. al. (1996) A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

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2.

Altshuler D et. al. (2000) Guilt by association.

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3.

Horikawa Y et. al. (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.

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4.

None (2001) Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene.

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5.

Kang ES et. al. (2006) A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes.

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6.

Ghosh S et. al. (1998) A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.

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7.

Cox NJ et. al. (1999) Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans.

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8.

Busfield F et. al. (2002) A genomewide search for type 2 diabetes-susceptibility genes in indigenous Australians.

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Update: Sept. 26, 2018