Disorders of sex development is a group of disorders characterized by disturbances of development, differentiation, and function of sexual organs. The disorder is caused by dysfunctional signaling systems.
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Gizard F et al. (2002) The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells. |
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Falardeau J et al. (2008) Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. |
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Nachtigal MW et al. (1998) Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression. |
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Tremblay A et al. (1999) Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1. |
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Bland ML et al. (2000) Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response. |
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Achermann JC et al. (2002) Gonadal determination and adrenal development are regulated by the orphan nuclear receptor steroidogenic factor-1, in a dose-dependent manner. |
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Wilhelm D et al. (2002) The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1. |
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Wikipedia article Wikipedia EN (Disorders_of_sex_development) |