Non-medullary thyroid cancer 2
Hereditary non-medullary thyroid cancer 2 is an autosomal dominant disorder caused by mutations of the SRGAP1 and MINPP1 genes. Also in tumors somatic mutation in the genes NRAS and HRAS are found.
He H et. al. (2013) SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility.[^]
Vriens MR et. al. (2009) Clinical features and genetic predisposition to hereditary nonmedullary thyroid cancer.[^]
Bonora E et. al. (2010) Genetic Predisposition to Familial Nonmedullary Thyroid Cancer: An Update of Molecular Findings and State-of-the-Art Studies.[^]