Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
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Susceptibility to autoimmune thyroid disease

Various loci are identified that are associated with autoimmune thyroid disorders such as Hashimoto thyroiditid and Grave disease.

Systematic

Disorder of the thyroid hormon system
Dysalbuminemic hyperthyroxinemia
Hyperthyroidism
Hypothyroidism
Susceptibility to autoimmune thyroid disease
Graves disease
GC
Susceptibility to autoimmune thyroid disease 1
Susceptibility to autoimmune thyroid disease 2
Susceptibility to autoimmune thyroid disease 3
TG
ZFAT
Susceptibility to autoimmune thyroid disease 4
Susceptibility to autoimmune thyroid disease 5
Thyroid cancer
Thyroid hormone resistance

References:

1.

Allen EM et al. (2003) A genome-wide scan for autoimmune thyroiditis in the Old Order Amish: replication of genetic linkage on chromosome 5q11.2-q14.3.

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2.

Collins JE et al. (2003) Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease.

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3.

Vaidya B et al. (2000) Evidence for a new Graves disease susceptibility locus at chromosome 18q21.

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4.

Merriman T et al. (1997) Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21.

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5.

Hodge SE et al. (1981) Close genetic linkage between diabetes mellitus and kidd blood group.

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6.

Invernizzi P et al. (2005) X chromosome monosomy: a common mechanism for autoimmune diseases.

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7.

Barbero P et al. (2004) Choanal atresia associated with prenatal methimazole exposure: three new patients.

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8.

MASI AT et al. (1965) HASHIMOTO'S DISEASE. AN EPIDEMIOLOGICAL CRITIQUE.

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9.

HALL R et al. (1964) PATERNAL TRANSMISSION OF THYROID AUTOIMMUNITY.

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10.

VOLPE R et al. (1963) Genetic factors in Hashimoto's struma.

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11.

HALL R et al. (1962) A study of the parents of patients with Hashimoto's disease.

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12.

Tomer Y et al. (2003) Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families.

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13.

Akamizu T et al. (2003) Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients.

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14.

Ueda H et al. (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.

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15.

Vaidya B et al. (2002) The genetics of autoimmune thyroid disease.

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16.

Ochi H et al. (2002) Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy.

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17.

Alkhateeb A et al. (2002) Mapping of an autoimmunity susceptibility locus (AIS1) to chromosome 1p31.3-p32.2.

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18.

Klintschar M et al. (2001) Evidence of fetal microchimerism in Hashimoto's thyroiditis.

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19.

Tomer Y et al. (1999) Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions.

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20.

Sakai K et al. (2001) Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese.

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21.

Shirasawa S et al. (2004) SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease.

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22.

Caturegli P et al. (2000) Hypothyroidism in transgenic mice expressing IFN-gamma in the thyroid.

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23.

Criswell LA et al. (2005) Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

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24.

Collins JE et al. (2004) Common allelic variants of exons 10, 12, and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the United Kingdom.

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25.

Ban Y et al. (2003) Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease.

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Update: Aug. 14, 2020
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