Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Susceptibility to autoimmune thyroid disease

Various loci are identified that are associated with autoimmune thyroid disorders such as Hashimoto thyroiditid and Grave disease.

Systematic

Disorder of the thyroid hormon system
Hyperthyroidism
Hypothyroidism
Susceptibility to autoimmune thyroid disease
Graves disease
GC
Susceptibility to autoimmune thyroid disease 1
Susceptibility to autoimmune thyroid disease 2
Susceptibility to autoimmune thyroid disease 3
TG
ZFAT
Susceptibility to autoimmune thyroid disease 4
Susceptibility to autoimmune thyroid disease 5
Thyroid cancer
Thyroid hormone resistance

References:

1.

Ban Y et. al. (2003) Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease.

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2.

Collins JE et. al. (2004) Common allelic variants of exons 10, 12, and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the United Kingdom.

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3.

Caturegli P et. al. (2000) Hypothyroidism in transgenic mice expressing IFN-gamma in the thyroid.

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4.

Sakai K et. al. (2001) Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese.

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5.

Shirasawa S et. al. (2004) SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease.

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6.

Hodge SE et. al. (1981) Close genetic linkage between diabetes mellitus and kidd blood group.

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7.

Merriman T et. al. (1997) Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21.

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8.

Vaidya B et. al. (2000) Evidence for a new Graves disease susceptibility locus at chromosome 18q21.

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9.

Tomer Y et. al. (2003) Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families.

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10.

Collins JE et. al. (2003) Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease.

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11.

Tomer Y et. al. (1999) Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions.

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12.

Klintschar M et. al. (2001) Evidence of fetal microchimerism in Hashimoto's thyroiditis.

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13.

Alkhateeb A et. al. (2002) Mapping of an autoimmunity susceptibility locus (AIS1) to chromosome 1p31.3-p32.2.

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14.

Ochi H et. al. (2002) Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy.

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15.

Vaidya B et. al. (2002) The genetics of autoimmune thyroid disease.

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16.

Allen EM et. al. (2003) A genome-wide scan for autoimmune thyroiditis in the Old Order Amish: replication of genetic linkage on chromosome 5q11.2-q14.3.

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17.

Ueda H et. al. (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.

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18.

Akamizu T et. al. (2003) Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients.

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19.

HALL R et. al. (1962) A study of the parents of patients with Hashimoto's disease.

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20.

VOLPE R et. al. (1963) Genetic factors in Hashimoto's struma.

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21.

HALL R et. al. (1964) PATERNAL TRANSMISSION OF THYROID AUTOIMMUNITY.

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22.

MASI AT et. al. (1965) HASHIMOTO'S DISEASE. AN EPIDEMIOLOGICAL CRITIQUE.

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23.

Barbero P et. al. (2004) Choanal atresia associated with prenatal methimazole exposure: three new patients.

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24.

Criswell LA et. al. (2005) Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

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25.

Invernizzi P et. al. (2005) X chromosome monosomy: a common mechanism for autoimmune diseases.

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Update: Sept. 26, 2018