Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Salt-sensitive essential hypertension

Susceptibility to salt-sensitive essential hypertension is associated with genetic variations.

Systematic

Hypertension
ACE
ACE2
AGT
Benign hyperproreninemia
Monogenic hypertension
Preeclampsia
Salt-sensitive essential hypertension
CYP3A5
VEGFC

References:

1.

Caulfield M et al. (1994) Linkage of the angiotensinogen gene to essential hypertension.

[^]
2.

Bonnardeaux A et al. (1994) Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.

[^]
3.

Julier C et al. (1997) Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10.

[^]
4.

Zhang Y et al. (2004) D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients.

[^]
5.

van Hooft IM et al. (1991) Renal hemodynamics and the renin-angiotensin-aldosterone system in normotensive subjects with hypertensive and normotensive parents.

[^]
6.

Rapp JP et al. (1989) A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure.

[^]
7.

Machnik A et al. (2009) Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.

[^]
8.

Dries DL et al. (2005) Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.

[^]
9.

Wang W et al. (2008) Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.

[^]
10.

Dong N et al. (2013) Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment.

[^]
11.

Gong M et al. (2003) Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p.

[^]
12.

Garay RP et al. (1979) A new test showing abnormal net Na+ and K+ fluxes in erythrocytes of essential hypertensive patients.

[^]
13.

None (1978) Normotension and hypertension: the mysterious viability of the false.

[^]
14.

Jacob HJ et al. (1991) Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.

[^]
15.

Hilbert P et al. (1991) Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.

[^]
16.

Parmer RJ et al. (1992) Baroreflex sensitivity and heredity in essential hypertension.

[^]
17.

Lifton RP et al. (1991) Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension.

[^]
18.

Rebbeck TR et al. (1991) Genetic and environmental explanations for the distribution of sodium-lithium countertransport in pedigrees from Rochester, MN.

[^]
19.

None (1991) Blood pressure control--special role of the kidneys and body fluids.

[^]
20.

Pérusse L et al. (1991) Evidence that a single gene with gender- and age-dependent effects influences systolic blood pressure determination in a population-based sample.

[^]
21.

Ravogli A et al. (1990) Early 24-hour blood pressure elevation in normotensive subjects with parental hypertension.

[^]
22.

None (1990) Inheritance of hypertension and blood pressure reactivity.

[^]
23.

Kagamimori S et al. (1985) Familial aggregation of red blood cell cation transport systems in Japanese families.

[^]
24.

None (1985) MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

[^]
25.

Hasstedt SJ et al. (1988) Hypertension and sodium-lithium countertransport in Utah pedigrees: evidence for major-locus inheritance.

[^]
26.

Hasstedt SJ et al. (1988) The inheritance of intraerythrocytic sodium level.

[^]
27.

None (1986) Red-cell lithium-sodium countertransport and renal lithium clearance in hypertension.

[^]
28.

Kurtz TW et al. (1985) Hypertension in the recently weaned Dahl salt-sensitive rat despite a diet deficient in sodium chloride.

[^]
29.

Parfrey PS et al. (1981) Blood pressure and hormonal changes following alteration in dietary sodium and potassium in young men with and without a familial predisposition to hypertension.

[^]
30.

de Wardener HE et al. (1982) The natriuretic hormone and essential hypertension.

[^]
31.

Clegg G et al. (1982) The heterogeneity of essential hypertension. Relation between lithium efflux and sodium content of erythrocytes and a family history of hypertension.

[^]
32.

None (1983) Genetics, environment, and hypertension.

[^]
33.

Garay RP et al. (1980) Inherited defect in a Na+, K-co-transport system in erythrocytes from essential hypertensive patients.

[^]
34.

De Mendonca M et al. (1980) Abnormal net Na+ and K+ fluxes in erythrocytes of three varieties of genetically hypertensive rats.

[^]
35.

Woods KL et al. (1981) Familial abnormality of erythrocyte cation transport in essential hypertension.

[^]
36.

Woods JW et al. (1983) Perturbation of sodium-lithium countertransport in red cells.

[^]
37.

Woods JW et al. (1982) Increased red-cell sodium-lithium countertransport in normotensive sons of hypertensive parents.

[^]
38.

Etkin NL et al. (1982) Racial differences in hypertension-associated red cell sodium permeability.

[^]
39.

Ibsen KK et al. () Essential hypertension: sodium-lithium countertransport in erythrocytes from patients and from children having one hypertensive parent.

[^]
40.

Garay RP et al. (1980) Laboratory distinction between essential and secondary hypertension by measurement of erythrocyte cation fluxes.

[^]
41.

Canessa M et al. (1980) Increased sodium-lithium countertransport in red cells of patients with essential hypertension.

[^]
42.

None (1980) Hypertension and the red cell.

[^]
43.

Trippodo NC et al. (1981) Similarities of genetic (spontaneous) hypertension. Man and rat.

[^]
44.

None (1995) Heterogeneous hypertension.

[^]
45.

Kreutz R et al. (1995) Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.

[^]
46.

Siffert W et al. (1995) Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension.

[^]
47.

Cicila GT et al. (1993) Linkage of 11 beta-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat.

[^]
48.

Dubay C et al. (1993) Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.

[^]
49.

Deng AY et al. (1994) Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.

[^]
50.

Benediktsson R et al. (1993) Glucocorticoid exposure in utero: new model for adult hypertension.

[^]
51.

Edwards CR et al. (1993) Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?

[^]
52.

Kurtz TW et al. (1993) Genetics of essential hypertension.

[^]
53.

Brown DM et al. (1996) Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat.

[^]
54.

Gu L et al. (1996) Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1.

[^]
55.

None (1996) Molecular genetics of human blood pressure variation.

[^]
56.

Wu DA et al. (1996) Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22.

[^]
57.

Frossard PM et al. (1995) Association between a dimorphic site on chromosome 12 and clinical diagnosis of hypertension in three independent populations.

[^]
58.

Pietruck F et al. (1996) Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated.

[^]
59.

Noon JP et al. (1997) Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure.

[^]
60.

Chiang FT et al. (1997) Association of the renin gene polymorphism with essential hypertension in a Chinese population.

[^]
61.

Churchill PC et al. (1997) Genetic susceptibility to hypertension-induced renal damage in the rat. Evidence based on kidney-specific genome transfer.

[^]
62.

Vincent M et al. (1997) A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist.

[^]
63.

Tanaka M et al. (1997) Genetically determined chloride-sensitive hypertension and stroke.

[^]
64.

Siffert W et al. (1998) Association of a human G-protein beta3 subunit variant with hypertension.

[^]
65.

Xu X et al. (1999) An extreme-sib-pair genome scan for genes regulating blood pressure.

[^]
66.

Baima J et al. (1999) Evidence for linkage between essential hypertension and a putative locus on human chromosome 17.

[^]
67.

Garbers DL et al. (1999) The molecular basis of hypertension.

[^]
68.

Glenn CL et al. (2000) Linkage and association of tumor necrosis factor receptor 2 locus with hypertension, hypercholesterolemia and plasma shed receptor.

[^]
69.

Lifton RP et al. (2001) Molecular mechanisms of human hypertension.

[^]
70.

Rutherford S et al. (2001) Chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension.

[^]
71.

Yamamoto N et al. (2002) Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension.

[^]
72.

Angius A et al. (2002) A new essential hypertension susceptibility locus on chromosome 2p24-p25, detected by genomewide search.

[^]
73.

Nakayama T et al. (2002) Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension.

[^]
74.

Funke-Kaiser H et al. (2003) Differential binding of transcription factor E2F-2 to the endothelin-converting enzyme-1b promoter affects blood pressure regulation.

[^]
75.

DAHL LK et al. (1962) Effects of chronia excess salt ingestion. Evidence that genetic factors play an important role in susceptibility to experimental hypertension.

[^]
76.

None (1963) Heredity in hypertension.

[^]
77.

MCDONOUGH JR et al. (1964) BLOOD PRESSURE AND HYPERTENSIVE DISEASE AMONG NEGROES AND WHITES; A STUDY IN EVANS COUNTY, GEORGIA.

[^]
78.

Rutherford S et al. (2004) Sibpair studies implicate chromosome 18 in essential hypertension.

[^]
79.

Koivukoski L et al. (2004) Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3.

[^]
80.

Gainer JV et al. (2005) Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.

[^]
81.

Zhu X et al. (2005) Admixture mapping for hypertension loci with genome-scan markers.

[^]
82.

Wallace C et al. (2006) Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension.

[^]
83.

Guzmán B et al. (2006) Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene.

[^]
84.

Chang YP et al. (2007) Multiple genes for essential-hypertension susceptibility on chromosome 1q.

[^]
85.

Rutherford S et al. (2007) A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study.

[^]
86.

Deo RC et al. (2007) A high-density admixture scan in 1,670 African Americans with hypertension.

[^]
87.

OMIM.ORG article

Omim 145500 [^]
Update: April 29, 2019