Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Somatic nephroblastoma

Wilms tumor (nephroblastoma) can be caused by somatic mutations of the genes GPC3, WT1, and BRCA2.

Systematic

Wilms tumor
Aniridia-Wilms-tumor syndrome
Denys-Drash syndrome
Somatic nephroblastoma
GPC3
WT1
WAGR syndrome

References:

1.

Yunis JJ et al. (1980) Familial occurrence of the aniridia-Wilms tumor syndrome with deletion 11p13-14.1.

external link
2.

Fearon ER et al. () Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours.

external link
3.

Reeve AE et al. () Loss of a Harvey ras allele in sporadic Wilms' tumour.

external link
4.

Orkin SH et al. () Development of homozygosity for chromosome 11p markers in Wilms' tumour.

external link
5.

Koufos A et al. () Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour.

external link
6.

de Martinville B et al. () The c-Ha-ras1, insulin and beta-globin loci map outside the deletion associated with aniridia-Wilms' tumour.

external link
7.

Huerre C et al. () c-Ha-ras1 is not deleted in aniridia-Wilms' tumour association.

external link
8.

McCoy FE et al. (1983) Glomerulonephritis associated with male pseudohermaphroditism and nephroblastoma.

external link
9.

Breslow NE et al. (1982) Epidemiological features of Wilms' tumor: results of the National Wilms' Tumor Study.

external link
10.

Kaneko Y et al. (1981) Interstitial deletion of short arm of chromosome 11 limited to Wilms' tumor cells in a patient without aniridia.

external link
11.

None (1981) Genetics of Wilms' tumor.

external link
12.

Cordero JF et al. (1980) Wilms tumor in five cousins.

external link
13.

Nordenskjöld A et al. (1995) Absence of mutations in the WT1 gene in patients with XY gonadal dysgenesis.

external link
14.

Babaian RJ et al. (1980) Wilms' tumor in the adult patient: diagnosis, management, and review of the world medical literature.

external link
15.

None (1980) Genes and cancer: the story of Wilms tumor.

external link
16.

Turleau C et al. (1984) Del 11p/aniridia complex. Report of three patients and review of 37 observations from the literature.

external link
17.

Nakagome Y et al. (1984) High-resolution studies in patients with aniridia-Wilms tumor association, Wilms tumor or related congenital abnormalities.

external link
18.

Ladda R et al. (1974) Computer-assisted analysis of chromosomal abnormalities: detection of a deletion in aniridia-Wilms' tumor syndrome.

external link
19.

Meadows AT et al. (1974) Wilms's tumor in three children of a woman with congenital hemihypertrophy.

external link
20.

Knudson AG et al. (1972) Mutation and cancer: a model for Wilms' tumor of the kidney.

external link
21.

Brown WT et al. (1972) Wilms' tumor in three successive generations.

external link
22.

Salazar H et al. (1972) Ultrastructure and observations on the histogenesis of mesotheliomas, "adenomatoid tumors", of the female genital tract.

external link
23.

Fraumeni JF et al. (1968) Wilms' tumor and congenital aniridia.

external link
24.

Denys P et al. () [Association of an anatomo-pathological syndrome of male pseudohermaphroditism, Wilms' tumor, parenchymatous nephropathy and XX/XY mosaicism].

external link
25.

Patek CE et al. (1999) A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome.

external link
26.

Royer-Pokora B et al. (2010) Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm.

external link
27.

Slade I et al. (2010) Constitutional translocation breakpoint mapping by genome-wide paired-end sequencing identifies HACE1 as a putative Wilms tumour susceptibility gene.

external link
28.

Regev M et al. (2008) Vertical transmission of a mutation in exon 1 of the WT1 gene: lessons for genetic counseling.

external link
29.

Reid S et al. (2005) Biallelic BRCA2 mutations are associated with multiple malignancies in childhood including familial Wilms tumour.

external link
30.

Anglesio MS et al. (2004) Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney.

external link
31.

FITZGERALD WL et al. (1955) Bilateral Wilms tumor in a Wilms tumor family: case report.

external link
32.

FRASIER SD et al. (1964) GONADOBLASTOMA ASSOCIATED WITH PURE GONADAL DYSGENESIS IN MONOZYGOUS TWINS.

external link
33.

None (1957) A Wilms' tumour family.

external link
34.

Lu YJ et al. (2002) Chromosome 1q expression profiling and relapse in Wilms' tumour.

external link
35.

Ruteshouser EC et al. (2001) Absence of PPP2R1A mutations in Wilms tumor.

external link
36.

None (1999) Wilms' tumor and related abnormalities in the fetus and newborn.

external link
37.

DiGeorge AM et al. (1966) The association of aniridia, Wilms' tumor, and genital abnormalities.

external link
38.

None (1998) Nephrogenic rests and the pathogenesis of Wilms tumor: developmental and clinical considerations.

external link
39.

McDonald JM et al. (1998) Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors.

external link
40.

Miyagawa K et al. (1998) Loss of WT1 function leads to ectopic myogenesis in Wilms' tumour.

external link
41.

Schumacher V et al. (1997) Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology.

external link
42.

Rahman N et al. (1996) Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12-q21.

external link
43.

Tsuchida Y et al. (1995) [Hereditary renal tumors: Wilms' tumor--congenital anomalies' syndrome].

external link
44.

Park S et al. (1993) Altered trans-activational properties of a mutated WT1 gene product in a WAGR-associated Wilms' tumor.

external link
45.

Park S et al. (1993) Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour.

external link
46.

Haber DA et al. (1993) WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.

external link
47.

Varanasi R et al. (1994) Fine structure analysis of the WT1 gene in sporadic Wilms tumors.

external link
48.

Haber DA et al. (1992) A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.

external link
49.

White GR et al. (2002) Somatic glypican 3 (GPC3) mutations in Wilms' tumour.

external link
50.

Kozman HM et al. (1989) Molecular genetic evidence for common pathogenesis of childhood and adult Wilms' tumor.

external link
51.

Kumar S et al. (1987) A cell line from Wilms' tumour with deletion in short arm of chromosome II.

external link
52.

Haber DA et al. (1990) An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.

external link
53.

None (1990) Molecular genetics. A gene for Wilms tumour?

external link
54.

van Heyningen V et al. (1990) Role for the Wilms tumor gene in genital development?

external link
55.

Jeanpierre C et al. (1990) Constitutional and somatic deletions of two different regions of maternal chromosome 11 in Wilms tumor.

external link
56.

Huff V et al. (1990) Parental origin of de novo constitutional deletions of chromosomal band 11p13.

external link
57.

Schwartz CE et al. (1991) Familial predisposition to Wilms tumor does not segregate with the WT1 gene.

external link
58.

Kakati S et al. (1991) Constitutional extra chromosomal element in a family with Wilms' tumor.

external link
59.

Ton CC et al. (1991) Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus.

external link
60.

de Ronde A et al. (1988) Morphological transformation by early region human polyomavirus BK DNA of human fibroblasts with deletions in the short arm of one chromosome 11.

external link
61.

Dressler GR et al. (1992) Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.

external link
62.

Blanchet P et al. (1977) XY gonadal dysgenesis with gonadoblastoma discovered after kidney transplantation.

external link
63.

Francke U et al. (1979) Aniridia-Wilms' tumor association: evidence for specific deletion of 11p13.

external link
64.

Knudson AG et al. (1975) Letter: Familial Wilms's tumor.

external link
65.

Juberg RC et al. (1975) Familial occurrence of Wilms' tumor: nephroblastoma in one of monozygous twins and in another sibling.

external link
66.

None (1975) Bilateral Wilms' tumour. Age at diagnosis, associated congenital anormalies, and possible pattern of inheritance.

external link
67.

MILLER RW et al. (1964) ASSOCIATION OF WILMS'S TUMOR WITH ANIRIDIA, HEMIHYPERTROPHY AND OTHER CONGENITAL MALFORMATIONS.

external link
68.

Narahara K et al. (1984) Regional mapping of catalase and Wilms tumoraniridia, genitourinary abnormalities, and mental retardation triad loci to the chromosome segment 11p1305--p1306.

external link
69.

Turleau C et al. (1984) Del11p13/nephroblastoma without aniridia.

external link
70.

Rivera MN et al. (2007) An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.

external link
71.

van Heyningen V et al. (1985) Molecular analysis of chromosome 11 deletions in aniridia-Wilms tumor syndrome.

external link
72.

None (1973) A general theory of carcinogenesis.

external link
73.

None (1973) Wilms' tumour in father and son.

external link
74.

Kaufman RL et al. (1973) Wilms' tumour in father and son.

external link
75.

None (1986) Chromosomal deletions and enzyme deficiencies.

external link
76.

Haning RV et al. (1985) A syndrome of chronic renal failure and XY gonadal dysgenesis in young phenotypic females without genital ambiguity.

external link
77.

Kinberg JA et al. (1987) Nephropathy-gonadal dysgenesis, type 2: renal failure in three siblings with XY dysgenesis in one.

external link
78.

Dao DD et al. (1987) Genetic mechanisms of tumor-specific loss of 11p DNA sequences in Wilms tumor.

external link
79.

Porteous DJ et al. (1987) HRAS1-selected chromosome transfer generates markers that colocalize aniridia- and genitourinary dysplasia-associated translocation breakpoints and the Wilms tumor gene within band 11p13.

external link
80.

Weissman BE et al. (1987) Introduction of a normal human chromosome 11 into a Wilms' tumor cell line controls its tumorigenic expression.

external link
81.

Seawright A et al. (1988) Analysis of WAGR deletions and related translocations with gene-specific DNA probes, using FACS-selected cell hybrids.

external link
82.

Scoggin CH et al. (1985) The E7-associated cell-surface antigen: a marker for the 11p13 chromosomal deletion associated with aniridia-Wilms tumor.

external link
83.

Scott J et al. () Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues.

external link
84.

Reeve AE et al. () Expression of insulin-like growth factor-II transcripts in Wilms' tumour.

external link
85.

Koufos A et al. () Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism.

external link
86.

Raizis AM et al. (1985) A mitotic recombination in Wilms tumor occurs between the parathyroid hormone locus and 11p13.

external link
87.

Michalopoulos EE et al. (1985) Molecular analysis of gene deletion in aniridia--Wilms tumor association.

external link
88.

Schroeder WT et al. (1987) Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors.

external link
89.

Mannens M et al. (1988) Molecular nature of genetic changes resulting in loss of heterozygosity of chromosome 11 in Wilms' tumours.

external link
90.

Huff V et al. (1988) Lack of linkage of familial Wilms' tumour to chromosomal band 11p13.

external link
91.

Grundy P et al. (1988) Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11.

external link
92.

Puissant H et al. (1988) Molecular analysis of a reciprocal translocation t(5;11) (q11;p13) in a WAGR patient.

external link
93.

OMIM.ORG article

Omim 194070 external link
94.

Wikipedia article

Wikipedia EN (Wilms's_tumor) external link
Update: Aug. 14, 2020
Copyright © 2005-2024 by Center for Nephrology and Metabolic Disorders, Dr. Mato Nagel, MD
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Germany, Tel.: +49-3576-287922, Fax: +49-3576-287944
Sitemap | Webmail | Disclaimer | Privacy Issues | Website Credits