Wilms tumor (nephroblastoma) can be caused by somatic mutations of the genes GPC3, WT1, and BRCA2.
Wilms tumor | ||||
Aniridia-Wilms-tumor syndrome | ||||
Denys-Drash syndrome | ||||
Somatic nephroblastoma | ||||
GPC3 | ||||
WT1 | ||||
WAGR syndrome | ||||
1. |
Yunis JJ et al. (1980) Familial occurrence of the aniridia-Wilms tumor syndrome with deletion 11p13-14.1. |
2. |
Fearon ER et al. () Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours. |
3. |
Reeve AE et al. () Loss of a Harvey ras allele in sporadic Wilms' tumour. |
4. |
Orkin SH et al. () Development of homozygosity for chromosome 11p markers in Wilms' tumour. |
5. |
Koufos A et al. () Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour. |
6. |
de Martinville B et al. () The c-Ha-ras1, insulin and beta-globin loci map outside the deletion associated with aniridia-Wilms' tumour. |
7. |
Huerre C et al. () c-Ha-ras1 is not deleted in aniridia-Wilms' tumour association. |
8. |
McCoy FE et al. (1983) Glomerulonephritis associated with male pseudohermaphroditism and nephroblastoma. |
9. |
Breslow NE et al. (1982) Epidemiological features of Wilms' tumor: results of the National Wilms' Tumor Study. |
10. |
Kaneko Y et al. (1981) Interstitial deletion of short arm of chromosome 11 limited to Wilms' tumor cells in a patient without aniridia. |
11. |
None (1981) Genetics of Wilms' tumor. |
12. |
Cordero JF et al. (1980) Wilms tumor in five cousins. |
13. |
Nordenskjöld A et al. (1995) Absence of mutations in the WT1 gene in patients with XY gonadal dysgenesis. |
14. |
Babaian RJ et al. (1980) Wilms' tumor in the adult patient: diagnosis, management, and review of the world medical literature. |
15. |
None (1980) Genes and cancer: the story of Wilms tumor. |
16. |
Turleau C et al. (1984) Del 11p/aniridia complex. Report of three patients and review of 37 observations from the literature. |
17. |
Nakagome Y et al. (1984) High-resolution studies in patients with aniridia-Wilms tumor association, Wilms tumor or related congenital abnormalities. |
18. |
Ladda R et al. (1974) Computer-assisted analysis of chromosomal abnormalities: detection of a deletion in aniridia-Wilms' tumor syndrome. |
19. |
Meadows AT et al. (1974) Wilms's tumor in three children of a woman with congenital hemihypertrophy. |
20. |
Knudson AG et al. (1972) Mutation and cancer: a model for Wilms' tumor of the kidney. |
21. |
Brown WT et al. (1972) Wilms' tumor in three successive generations. |
22. |
Salazar H et al. (1972) Ultrastructure and observations on the histogenesis of mesotheliomas, "adenomatoid tumors", of the female genital tract. |
23. |
Fraumeni JF et al. (1968) Wilms' tumor and congenital aniridia. |
24. |
Denys P et al. () [Association of an anatomo-pathological syndrome of male pseudohermaphroditism, Wilms' tumor, parenchymatous nephropathy and XX/XY mosaicism]. |
25. |
Patek CE et al. (1999) A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome. |
26. |
Royer-Pokora B et al. (2010) Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm. |
27. |
Slade I et al. (2010) Constitutional translocation breakpoint mapping by genome-wide paired-end sequencing identifies HACE1 as a putative Wilms tumour susceptibility gene. |
28. |
Regev M et al. (2008) Vertical transmission of a mutation in exon 1 of the WT1 gene: lessons for genetic counseling. |
29. |
Reid S et al. (2005) Biallelic BRCA2 mutations are associated with multiple malignancies in childhood including familial Wilms tumour. |
30. |
Anglesio MS et al. (2004) Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney. |
31. |
FITZGERALD WL et al. (1955) Bilateral Wilms tumor in a Wilms tumor family: case report. |
32. |
FRASIER SD et al. (1964) GONADOBLASTOMA ASSOCIATED WITH PURE GONADAL DYSGENESIS IN MONOZYGOUS TWINS. |
33. |
None (1957) A Wilms' tumour family. |
34. |
Lu YJ et al. (2002) Chromosome 1q expression profiling and relapse in Wilms' tumour. |
35. |
Ruteshouser EC et al. (2001) Absence of PPP2R1A mutations in Wilms tumor. |
36. |
None (1999) Wilms' tumor and related abnormalities in the fetus and newborn. |
37. |
DiGeorge AM et al. (1966) The association of aniridia, Wilms' tumor, and genital abnormalities. |
38. |
None (1998) Nephrogenic rests and the pathogenesis of Wilms tumor: developmental and clinical considerations. |
39. |
McDonald JM et al. (1998) Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors. |
40. |
Miyagawa K et al. (1998) Loss of WT1 function leads to ectopic myogenesis in Wilms' tumour. |
41. |
Schumacher V et al. (1997) Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology. |
42. |
Rahman N et al. (1996) Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12-q21. |
43. |
Tsuchida Y et al. (1995) [Hereditary renal tumors: Wilms' tumor--congenital anomalies' syndrome]. |
44. |
Park S et al. (1993) Altered trans-activational properties of a mutated WT1 gene product in a WAGR-associated Wilms' tumor. |
45. |
Park S et al. (1993) Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour. |
46. |
Haber DA et al. (1993) WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant. |
47. |
Varanasi R et al. (1994) Fine structure analysis of the WT1 gene in sporadic Wilms tumors. |
48. |
Haber DA et al. (1992) A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells. |
49. |
White GR et al. (2002) Somatic glypican 3 (GPC3) mutations in Wilms' tumour. |
50. |
Kozman HM et al. (1989) Molecular genetic evidence for common pathogenesis of childhood and adult Wilms' tumor. |
51. |
Kumar S et al. (1987) A cell line from Wilms' tumour with deletion in short arm of chromosome II. |
52. |
Haber DA et al. (1990) An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor. |
53. |
None (1990) Molecular genetics. A gene for Wilms tumour? |
54. |
van Heyningen V et al. (1990) Role for the Wilms tumor gene in genital development? |
55. |
Jeanpierre C et al. (1990) Constitutional and somatic deletions of two different regions of maternal chromosome 11 in Wilms tumor. |
56. |
Huff V et al. (1990) Parental origin of de novo constitutional deletions of chromosomal band 11p13. |
57. |
Schwartz CE et al. (1991) Familial predisposition to Wilms tumor does not segregate with the WT1 gene. |
58. |
Kakati S et al. (1991) Constitutional extra chromosomal element in a family with Wilms' tumor. |
59. |
Ton CC et al. (1991) Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus. |
60. |
de Ronde A et al. (1988) Morphological transformation by early region human polyomavirus BK DNA of human fibroblasts with deletions in the short arm of one chromosome 11. |
61. |
Dressler GR et al. (1992) Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor. |
62. |
Blanchet P et al. (1977) XY gonadal dysgenesis with gonadoblastoma discovered after kidney transplantation. |
63. |
Francke U et al. (1979) Aniridia-Wilms' tumor association: evidence for specific deletion of 11p13. |
64. |
Knudson AG et al. (1975) Letter: Familial Wilms's tumor. |
65. |
Juberg RC et al. (1975) Familial occurrence of Wilms' tumor: nephroblastoma in one of monozygous twins and in another sibling. |
66. |
None (1975) Bilateral Wilms' tumour. Age at diagnosis, associated congenital anormalies, and possible pattern of inheritance. |
67. |
MILLER RW et al. (1964) ASSOCIATION OF WILMS'S TUMOR WITH ANIRIDIA, HEMIHYPERTROPHY AND OTHER CONGENITAL MALFORMATIONS. |
68. |
Narahara K et al. (1984) Regional mapping of catalase and Wilms tumoraniridia, genitourinary abnormalities, and mental retardation triad loci to the chromosome segment 11p1305--p1306. |
69. |
Turleau C et al. (1984) Del11p13/nephroblastoma without aniridia. |
70. |
Rivera MN et al. (2007) An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. |
71. |
van Heyningen V et al. (1985) Molecular analysis of chromosome 11 deletions in aniridia-Wilms tumor syndrome. |
72. |
None (1973) A general theory of carcinogenesis. |
73. |
None (1973) Wilms' tumour in father and son. |
74. |
Kaufman RL et al. (1973) Wilms' tumour in father and son. |
75. |
None (1986) Chromosomal deletions and enzyme deficiencies. |
76. |
Haning RV et al. (1985) A syndrome of chronic renal failure and XY gonadal dysgenesis in young phenotypic females without genital ambiguity. |
77. |
Kinberg JA et al. (1987) Nephropathy-gonadal dysgenesis, type 2: renal failure in three siblings with XY dysgenesis in one. |
78. |
Dao DD et al. (1987) Genetic mechanisms of tumor-specific loss of 11p DNA sequences in Wilms tumor. |
80. |
Weissman BE et al. (1987) Introduction of a normal human chromosome 11 into a Wilms' tumor cell line controls its tumorigenic expression. |
81. |
Seawright A et al. (1988) Analysis of WAGR deletions and related translocations with gene-specific DNA probes, using FACS-selected cell hybrids. |
82. |
Scoggin CH et al. (1985) The E7-associated cell-surface antigen: a marker for the 11p13 chromosomal deletion associated with aniridia-Wilms tumor. |
83. |
Scott J et al. () Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues. |
84. |
Reeve AE et al. () Expression of insulin-like growth factor-II transcripts in Wilms' tumour. |
85. |
Koufos A et al. () Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism. |
86. |
Raizis AM et al. (1985) A mitotic recombination in Wilms tumor occurs between the parathyroid hormone locus and 11p13. |
87. |
Michalopoulos EE et al. (1985) Molecular analysis of gene deletion in aniridia--Wilms tumor association. |
88. |
Schroeder WT et al. (1987) Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors. |
89. |
Mannens M et al. (1988) Molecular nature of genetic changes resulting in loss of heterozygosity of chromosome 11 in Wilms' tumours. |
90. |
Huff V et al. (1988) Lack of linkage of familial Wilms' tumour to chromosomal band 11p13. |
91. |
Grundy P et al. (1988) Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11. |
92. |
Puissant H et al. (1988) Molecular analysis of a reciprocal translocation t(5;11) (q11;p13) in a WAGR patient. |
93. |
OMIM.ORG article Omim 194070 |
94. |
Wikipedia article Wikipedia EN (Wilms's_tumor) |