Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Ligneous conjunctivitis

Conjunctivitis lignosa is an autosoml recessive disorder caused by mutations of the PLG gene and the resulting hypoplasminogenemia. The chronic conjunctivitis is characterized by pseudomembranes.

Systematic

Hereditary ocular disease and visual impairment
Aplasia of lacrimal and salivary glands
Fish-eye disease
Hereditary glaucoma
IVIC syndrome
Knobloch syndrome 1
Lacrimoauriculodentodigital syndrome
Ligneous conjunctivitis
PLG
Macular degeneration
Manitoba oculotrichoanal syndrome
Papillorenal syndrome
Retinitis pigmentosa
Syndromic microphthalmia 6
Usher syndrome

References:

1.

Aoki N et al. (1978) Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis.

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2.

Shigekiyo T et al. (1992) Type I congenital plasminogen deficiency is not a risk factor for thrombosis.

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3.

None (1990) Ligneous conjunctivitis: an ophthalmic disease with potentially fatal tracheobronchial obstruction. Laryngeal and tracheobronchial features.

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4.

Dolan G et al. (1988) Thrombovascular disease and familial plasminogen deficiency: a report of three kindreds.

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5.

Bateman JB et al. () Ligneous conjunctivitis: an autosomal recessive disorder.

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6.

Tait RC et al. (1996) Isolated familial plasminogen deficiency may not be a risk factor for thrombosis.

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7.

Schuster V et al. (1997) Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.

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8.

Drew AF et al. (1998) Ligneous conjunctivitis in plasminogen-deficient mice.

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9.

Kao WW et al. (1998) Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice.

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10.

Schott D et al. (1998) Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency.

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11.

Schuster V et al. (1999) Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis.

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12.

Schuster V et al. () Ligneous conjunctivitis.

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13.

Tefs K et al. (2006) Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients.

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14.

Marcus DM et al. (1990) Ligneous conjunctivitis with ear involvement.

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15.

Nüssgens Z et al. (1993) Ligneous conjunctivitis. Ten years follow-up.

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16.

Ramsey DT et al. () Ligneous conjunctivitis in four Doberman pinschers.

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17.

Mingers AM et al. (1997) Homozygous type I plasminogen deficiency.

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18.

OMIM.ORG article

Omim 217090 [^]
19.

Orphanet article

Orphanet ID 97231 [^]
20.

Wikipedia article

Wikipedia EN (Ligneous_conjunctivitis) [^]
Update: April 29, 2019