Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Hereditary papillary renal cell carcinoma 1

Familial papillary renal cell carcinoma type 1 is caused by mutations of the MET gene. The disorder is characterized by multifocal papillary renal carcinoma. Also somatic mutation are observed in sporadic cases.

Systematic

Hereditary papillary renal cell carcinoma
Hereditary papillary renal cell carcinoma 1
MET
PRCC

References:

1.

Schmidt L et al. (1997) Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas.

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2.

Zhuang Z et al. (1998) Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas.

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3.

Cohen AJ et al. (1979) Hereditary renal-cell carcinoma associated with a chromosomal translocation.

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4.

Cohen HT et al. (2005) Renal-cell carcinoma.

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5.

Bodmer D et al. (2002) Understanding familial and non-familial renal cell cancer.

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6.

Kuiper RP et al. (2003) Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution.

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7.

Kovacs G et al. (1997) The Heidelberg classification of renal cell tumours.

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8.

Mancilla-Jimenez R et al. (1976) Papillary renal cell carcinoma: a clinical, radiologic, and pathologic study of 34 cases.

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9.

Kovacs G et al. (1991) Cytogenetics of papillary renal cell tumors.

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10.

Zbar B et al. (1995) Hereditary papillary renal cell carcinoma: clinical studies in 10 families.

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11.

None (1993) Molecular cytogenetics of renal cell tumors.

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12.

Zbar B et al. (1994) Hereditary papillary renal cell carcinoma.

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13.

Fischer J et al. (1998) Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours.

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14.

Balint I et al. (1999) Mapping the papillary renal cell carcinoma gene between loci D17S787 and D17S1799 on chromosome 17q21.32.

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15.

Kuroda N et al. (2003) Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects.

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16.

Yang XJ et al. (2005) A molecular classification of papillary renal cell carcinoma.

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17.

None (2011) Hereditary leiomyomatosis and renal cell cancer: update on clinical and molecular characteristics.

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18.

OMIM.ORG article

Omim 605074 [^]
19.

Orphanet article

Orphanet ID 319298 [^]
Update: April 29, 2019