Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Hereditary papillary renal cell carcinoma

Familial papillary renal cell carcinoma is a genetic disposition to bilateral multifocal tumors of such type. It is caused by translocation affecting the PRCC gene or in type 1 mutations of the MET gene.

Systematic

Hereditary renal tumors
Hereditary leiomyomatosis and renal cell cancer
Hereditary papillary renal cell carcinoma
Hereditary papillary renal cell carcinoma 1
MET
PRCC
Nonpapillary renal cell carcinoma
Wilms tumor
von Hippel-Lindau syndrome

References:

1.

Schmidt L et al. (1997) Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas.

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2.

Zhuang Z et al. (1998) Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas.

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3.

Cohen AJ et al. (1979) Hereditary renal-cell carcinoma associated with a chromosomal translocation.

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4.

Cohen HT et al. (2005) Renal-cell carcinoma.

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5.

Bodmer D et al. (2002) Understanding familial and non-familial renal cell cancer.

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6.

Kuiper RP et al. (2003) Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution.

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7.

Kovacs G et al. (1997) The Heidelberg classification of renal cell tumours.

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8.

Mancilla-Jimenez R et al. (1976) Papillary renal cell carcinoma: a clinical, radiologic, and pathologic study of 34 cases.

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9.

Kovacs G et al. (1991) Cytogenetics of papillary renal cell tumors.

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10.

Zbar B et al. (1995) Hereditary papillary renal cell carcinoma: clinical studies in 10 families.

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11.

None (1993) Molecular cytogenetics of renal cell tumors.

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12.

Zbar B et al. (1994) Hereditary papillary renal cell carcinoma.

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13.

Fischer J et al. (1998) Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours.

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14.

Balint I et al. (1999) Mapping the papillary renal cell carcinoma gene between loci D17S787 and D17S1799 on chromosome 17q21.32.

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15.

Kuroda N et al. (2003) Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects.

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16.

Yang XJ et al. (2005) A molecular classification of papillary renal cell carcinoma.

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17.

None (2011) Hereditary leiomyomatosis and renal cell cancer: update on clinical and molecular characteristics.

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18.

OMIM.ORG article

Omim 605074 [^]
19.

Orphanet article

Orphanet ID 47044 [^]
Update: April 29, 2019