Osteoarthritis susceptibility 5
Some genetic variants of the GDF5 gene seem to indicate osteoarthritis susceptibility, of the hip in paticular.
Miyamoto Y et al. (2007) A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis.[^]
Masuya H et al. (2007) A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice.[^]
Dodd AW et al. (2013) A rare variant in the osteoarthritis-associated locus GDF5 is functional and reveals a site that can be manipulated to modulate GDF5 expression.[^]
OMIM.ORG articleOmim 612400 [^]