Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Acute myeloid leukemia

Acute myeloid leukemia is characterized by rapid growth and amplification of white blood cells and their precursors in the bone marrow. This clone of blood cells replaces all thoe other normal blood cell lines. The disease may be caused by JAK2 gene mutations.

Systematic

Hereditary malign blood disorders
Acute myeloid leukemia
JAK2
Juvenile myelomonocytic leukemia
Myelodysplastic syndrome
Myelofibrosis
Noonan syndrome-like disorder and juvenile myelomonocytic leukemia
Polycythemia vera
Somatic erythrocytosis
Susceptibility to acute myeloid leukemia
Susceptibility to myelodysplastic syndrome

References:

1.

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2.

Smith ML et al. (2004) Mutation of CEBPA in familial acute myeloid leukemia.

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3.

Matsunaga T et al. (2003) Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia.

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4.

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5.

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6.

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7.

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8.

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9.

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10.

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11.

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12.

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13.

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14.

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15.

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16.

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17.

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18.

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19.

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20.

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21.

Barjesteh van Waalwijk van Doorn-Khosrovani S et al. (2005) Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia.

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22.

Jin L et al. (2006) Targeting of CD44 eradicates human acute myeloid leukemic stem cells.

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23.

Mullican SE et al. (2007) Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia.

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24.

Gale RE et al. (2008) The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia.

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25.

Garzon R et al. (2008) Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin.

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26.

Schlenk RF et al. (2008) Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.

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27.

Calado RT et al. (2009) Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia.

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28.

Delhommeau F et al. (2009) Mutation in TET2 in myeloid cancers.

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29.

Garzon R et al. (2009) MicroRNA 29b functions in acute myeloid leukemia.

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30.

Marcucci G et al. (2010) IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.

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31.

Harutyunyan A et al. (2011) p53 lesions in leukemic transformation.

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32.

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33.

Ding L et al. (2012) Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.

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34.

Smith CC et al. (2012) Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.

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35.

Venstrom JM et al. (2012) HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1.

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36.

Santos MA et al. (2014) DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.

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37.

Wong TN et al. (2015) Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.

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38.

Illendula A et al. (2015) Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice.

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39.

Fong CY et al. (2015) BET inhibitor resistance emerges from leukaemia stem cells.

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40.

Rathert P et al. (2015) Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.

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41.

Ivey A et al. (2016) Assessment of Minimal Residual Disease in Standard-Risk AML.

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42.

Feng B et al. (1999) Genetic studies on a family with acute myelogenous leukemia.

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43.

Raffel S et al. (2017) BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.

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44.

OMIM.ORG article

Omim 601626 [^]
45.

Orphanet article

Orphanet ID 519 [^]
46.

Wikipedia article

Wikipedia EN (Acute_myeloid_leukemia) [^]
Update: April 29, 2019