Thrombocythemia 3 is an autosomal dominant disorder caused by Mutations of the JAK2 gene which is characterized by elevated platelet counts.
Baxter EJ et. al. () Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.[^]
Kralovics R et. al. (2005) A gain-of-function mutation of JAK2 in myeloproliferative disorders.[^]
Mead AJ et. al. (2012) Germline JAK2 mutation in a family with hereditary thrombocytosis.[^]
Singal U et. al. (1983) Essential thrombocythemia: a clonal disorder of hematopoietic stem cell.[^]
Gaetani GF et. al. (1982) Primary thrombocythemia: clonal origin of platelets, erythrocytes, and granulocytes in a GdB/GdMediterranean subject.[^]
Fialkow PJ et. al. (1981) Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell.[^]
Lata K et. al. (2010) JAK2 mutations and coronary ischemia.[^]