Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Atopy

Atopy is an inborn allergic reaction mediated by immunoglobulin E. It may accur on all surfaces that come into contact with the allergogenic substance (skin, gastro intestinal tract, respiratory tract).

Systematic

Hereditary immunological disorders
Atopy
MS4A2
Chronic inflammatory disorders
Hereditary complement disorders
Immunoglobulin disorders
Primary immunodeficiency
Susceptibility to allergic rhinitis
Susceptibility to asthma

References:

1.

Hizawa N et. al. (1995) Association between high serum total IgE levels and D11S97 on chromosome 11q13 in Japanese subjects.

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2.

Sandford AJ et. al. (1993) Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q.

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3.

Shin HD et. al. (2004) Association of tumor necrosis factor polymorphisms with asthma and serum total IgE.

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4.

Lympany P et. al. (1992) Genetic analysis using DNA polymorphism of the linkage between chromosome 11q13 and atopy and bronchial hyperresponsiveness to methacholine.

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5.

Amelung PJ et. al. (1992) Atopy and bronchial hyperresponsiveness: exclusion of linkage to markers on chromosomes 11q and 6p.

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6.

Palmer LJ et. al. (2000) Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families.

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7.

Moffatt MF et. al. (2001) Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample.

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8.

Anderson GG et. al. (2002) Positive association to IgE levels and a physical map of the 13q14 atopy locus.

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9.

Zhang Y et. al. (2003) Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.

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10.

Shin HD et. al. (2003) Association of Eotaxin gene family with asthma and serum total IgE.

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11.

Hysi P et. al. (2005) NOD1 variation, immunoglobulin E and asthma.

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12.

Bottazzo GF et. al. (1976) Separate autoantibodies to human pancreatic glucagon and somatostatin cells.

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13.

Gerrard JW et. al. (1978) A genetic study of immunoglobulin E.

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14.

Marsh DG et. al. (1992) A major gene for allergy--fact or fancy?

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15.

Cookson WO et. al. (1992) Maternal inheritance of atopic IgE responsiveness on chromosome 11q.

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16.

None (1992) John Bostock, hay fever, and the mechanism of allergy.

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17.

Lympany P et. al. (1992) Genetic analysis of the linkage between chromosome 11q and atopy.

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18.

Moffatt MF et. al. (1992) Factors confounding genetic linkage between atopy and chromosome 11q.

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19.

Hizawa N et. al. (1992) Lack of linkage between atopy and locus 11q13.

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20.

Rich SS et. al. (1992) Genetic analysis of atopy in three large kindreds: no evidence of linkage to D11S97.

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21.

None (1992) Genetic linkage: interpreting lod scores.

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22.

Young RP et. al. (1992) Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13.

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23.

Hanson B et. al. (1991) Atopic disease and immunoglobulin E in twins reared apart and together.

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24.

Cookson WO et. al. (1989) Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q.

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25.

Cookson WO et. al. (1988) Dominant inheritance of atopic immunoglobulin-E responsiveness.

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26.

Jeffreys AJ et. al. () Hypervariable 'minisatellite' regions in human DNA.

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27.

Marsh DG et. al. (1974) Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity.

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28.

Morton NE et. al. (1974) Analysis of family resemblance. 3. Complex segregation of quantitative traits.

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29.

None (1972) Emperic risks for genetic counseling in families with allergy.

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30.

Meyers DA et. al. (1983) The inheritance of immunoglobulin E: genetic linkage analysis.

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31.

Hasstedt SJ et. al. (1983) Inheritance of immunoglobulin E: genetic model fitting.

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32.

Blumenthal MN et. al. (1981) Genetic transmission of serum IgE Levels.

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33.

Rao DC et. al. (1980) Immunoglobulin E revisited.

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34.

Shirakawa T et. al. (1994) Linkage between severe atopy and chromosome 11q13 in Japanese families.

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35.

Coleman R et. al. (1993) Chromosome 11q13 and atopy underlying atopic eczema.

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36.

Collée JM et. al. (1993) Allele sharing on chromosome 11q13 in sibs with asthma and atopy.

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37.

Kimura K et. al. (1999) Linkage and association of atopic asthma to markers on chromosome 13 in the Japanese population.

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38.

Oettgen HC et. al. (1999) IgE in asthma and atopy: cellular and molecular connections.

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39.

Milgrom H et. al. (1999) Treatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 Study Group.

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40.

Wheatley AP et. al. (2002) Identification of the autoantigen SART-1 as a candidate gene for the development of atopy.

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41.

Hargrave S et. al. (2003) Preliminary findings in corneal allograft rejection in patients with keratoconus.

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42.

Hecker M et. al. (2003) Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females.

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43.

None (1954) A study of the inheritance of atopic hypersensitivity in man.

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44.

None (1960) Prurigo Besnier (atopic dermatitis) with special reference to the role of allergic factors. I. The influence of atopic hereditary factors.

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45.

Sharma S et. al. (2005) A novel (TG)n(GA)m repeat polymorphism 254 bp downstream of the mast cell chymase (CMA1) gene is associated with atopic asthma and total serum IgE levels.

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46.

Mathias RA et. al. (2005) Inheritance of total serum IgE in the isolated Tangier Island population from Virginia: complexities associated with genealogical depth of pedigrees in segregation analyses.

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Update: Sept. 26, 2018