Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Migraine

Migraine is a periodic headache that runs in families. Several genetic factors influencing susceptibility have been identified.

Systematic

Hereditary neurological disorders
Alzheimer disease
Arts syndrome
Autism
Autosomal dominant cerebellar ataxia, deafness and narcolepsy
Autosomal recessive spastic paraplegia type 44
Brain malformations with urinary tract defects
Brain small vessel disease with hemorrhage
Brunner syndrome
Charcot-Marie-Tooth disease
Congenital insensitivity to pain with anhidrosis
Hereditary benign chorea
Hereditary distal motor neuron neuropathy type 5A
Hereditary muscle diseases
Hereditary sensory and autonomic neuropathy type 2A
Hereditary sensory neuropathy type 1E
Hypokalemic periodic paralysis 1
Hypomyelinating Leukodystrophy 2
Idiopathic basal ganglia calcification 1
Intellectual disability-severe speech delay-mild dysmorphism syndrome
Migraine
TNF
Nemaline myopathy 5
Porencephaly
Rett syndrome
Severe neonatal-onset encephalopathy with microcephaly
Spastic paraplegia 17 with amyotrophy of hands and feet
Susceptibility to glioma
Vascular dementia
X-linked syndromic mental retardation 13

References:

1.

None (1977) Migraine in twins.

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2.

Goadsby PJ et. al. (1990) Vasoactive peptide release in the extracerebral circulation of humans during migraine headache.

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3.

Stewart WF et. al. (1992) Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors.

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4.

Hiner BC et. al. (1986) Antimigraine drug interactions with 5-hydroxytryptamine1A receptors.

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5.

Devoto M et. al. (1986) Segregation analysis of migraine in 128 families.

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6.

None (1985) Migraine and muscle contraction headaches: a continuum.

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7.

Glover V et. al. (1983) Biochemical predisposition to dietary migraine: the role of phenolsulphotransferase.

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8.

Russell MB et. al. (1993) Familial occurrence of migraine without aura and migraine with aura.

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9.

Russell MB et. al. (1995) Inheritance of migraine investigated by complex segregation analysis.

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10.

Stewart WF et. al. (1996) Variation in migraine prevalence by race.

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11.

Ulrich V et. al. (1997) Analysis of 31 families with an apparently autosomal-dominant transmission of migraine with aura in the nuclear family.

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12.

Ulrich V et. al. (1999) Evidence of a genetic factor in migraine with aura: a population-based Danish twin study.

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13.

Gervil M et. al. (1999) Migraine without aura: a population-based twin study.

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14.

Kowa H et. al. (2000) The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine.

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15.

Wessman M et. al. (2002) A susceptibility locus for migraine with aura, on chromosome 4q24.

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16.

Reuter U et. al. (2002) Nuclear factor-kappaB as a molecular target for migraine therapy.

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17.

Lassen LH et. al. (2002) CGRP may play a causative role in migraine.

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18.

GOODELL H et. al. (1954) Familiar occurrence of migraine headache: a study of heredity.

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19.

None (1965) MIGRAINE AND HEREDITY.

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20.

Björnsson A et. al. (2003) Localization of a gene for migraine without aura to chromosome 4q21.

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21.

Olesen J et. al. (2004) Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine.

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22.

Oterino A et. al. (2004) MTHFR T677 homozygosis influences the presence of aura in migraineurs.

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23.

Scher AI et. al. (2006) Migraine and MTHFR C677T genotype in a population-based sample.

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24.

Ludvigsson P et. al. (2006) Migraine with aura is a risk factor for unprovoked seizures in children.

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25.

Stewart WF et. al. (2006) Familial risk of migraine: variation by proband age at onset and headache severity.

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26.

Anttila V et. al. (2006) Trait components provide tools to dissect the genetic susceptibility of migraine.

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27.

Stam AH et. al. (2010) Shared genetic factors in migraine and depression: evidence from a genetic isolate.

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28.

Karatas H et. al. (2013) Spreading depression triggers headache by activating neuronal Panx1 channels.

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29.

Anttila V et. al. (2013) Genome-wide meta-analysis identifies new susceptibility loci for migraine.

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Update: Sept. 26, 2018