Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Preeclampsia

Preeclampsia is a disease of pregnancy that occurs after the 20th week of gestation. It is characterized by hypertension and proteinuria and it can develop into a life threatening eclampsia. The cause sometimes can be found in hereditary factors and complement dysregulation.

Systematic

Hypertension
ACE
ACE2
AGT
Benign hyperproreninemia
Monogenic hypertension
Preeclampsia
APOL1
Preeclampsia 1
Preeclampsia 2
Preeclampsia 3
Preeclampsia 4
STOX1
Preeclampsia 5
CORIN
Salt-sensitive essential hypertension
VEGFC

References:

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2.

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3.

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4.

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26.

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Page NM et al. (2000) Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia.

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Laasanen J et al. (2002) Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia.

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37.

Maynard SE et al. (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.

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38.

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39.

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40.

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41.

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42.

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43.

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44.

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45.

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46.

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47.

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48.

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49.

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50.

van Dijk M et al. (2012) HELLP babies link a novel lincRNA to the trophoblast cell cycle.

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51.

Oudejans CB et al. (2015) Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia.

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52.

Orphanet article

Orphanet ID 275555 [^]
53.

Wikipedia article

Wikipedia EN (Pre-eclampsia) [^]
Update: April 29, 2019