Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Preeclampsia 4

Preeclampsia 4 is a disease of pregnancy that occurs after the 20th week of gestation. It is characterized by hypertension and proteinuria and it can develop into a life threatening eclampsia. The gene responsible is STOX1 and inheritance is probably autosomal dominant.

Systematic

Preeclampsia
APOL1
Preeclampsia 1
Preeclampsia 2
Preeclampsia 3
Preeclampsia 4
STOX1
Preeclampsia 5

References:

1.

van Dijk M et al. (2005) Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family.

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2.

Kivinen K et al. (2007) Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample.

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3.

Lachmeijer AM et al. (2001) A genome-wide scan for preeclampsia in the Netherlands.

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4.

Oudejans CB et al. (2004) The parent-of-origin effect of 10q22 in pre-eclamptic females coincides with two regions clustered for genes with down-regulated expression in androgenetic placentas.

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5.

OMIM.ORG article

Omim 609404 [^]
Update: April 29, 2019