Preeclampsia 4 is a disease of pregnancy that occurs after the 20th week of gestation. It is characterized by hypertension and proteinuria and it can develop into a life threatening eclampsia. The gene responsible is STOX1 and inheritance is probably autosomal dominant.
van Dijk M et. al. (2005) Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family.[^]
Kivinen K et. al. (2007) Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample.[^]
Lachmeijer AM et. al. (2001) A genome-wide scan for preeclampsia in the Netherlands.[^]
Oudejans CB et. al. (2004) The parent-of-origin effect of 10q22 in pre-eclamptic females coincides with two regions clustered for genes with down-regulated expression in androgenetic placentas.[^]