Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Preeclampsia 4 is a disease of pregnancy that occurs after the 20th week of gestation. It is characterized by hypertension and proteinuria and it can develop into a life threatening eclampsia. The gene responsible is STOX1 and inheritance is probably autosomal dominant.
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van Dijk M et al. (2005) Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. 
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| 2. |
Kivinen K et al. (2007) Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample.
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| 3. |
Lachmeijer AM et al. (2001) A genome-wide scan for preeclampsia in the Netherlands.
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| 4. |
Oudejans CB et al. (2004) The parent-of-origin effect of 10q22 in pre-eclamptic females coincides with two regions clustered for genes with down-regulated expression in androgenetic placentas.
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| 5. |
OMIM.ORG article Omim 609404
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