Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Gastric cancer risk

The risk of malignant neoplasm can be conditioned by genetic variants in the IL1RN gene which encodes an interleukin 1.

Systematic

Hereditary tumors
Capillary infantile hemangioma
Carcinoid tumor of lung
Gastric cancer
Hereditary brain tumors
Hereditary malign blood disorders
Hereditary renal tumors
Lymphangiomyomatosis
Multiple self-healing palmoplantar carcinoma
Neurofibromatosis
Susceptibility to Kaposi sarcoma
lipoma

References:

1.

Huntsman DG et al. (2001) Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations.

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2.

van der Post RS et. al. (2015) Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.

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3.

Benusiglio PR et. al. (2013) CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study.

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4.

Fitzgerald RC et. al. (2010) Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research.

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5.

Oliveira C et. al. (2009) Germline CDH1 deletions in hereditary diffuse gastric cancer families.

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6.

Frebourg T et. al. (2006) Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer.

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7.

Brooks-Wilson AR et. al. (2004) Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria.

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8.

None (1965) THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION.

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9.

None (1964) FAMILIAL GASTRIC CANCER.

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10.

Oliveira C et. al. (2002) Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred.

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11.

Chun YS et. al. (2001) Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated?

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12.

None (1988) A human model of gastric carcinogenesis.

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13.

Lynch HT et. al. (2000) E-cadherin mutation-based genetic counseling and hereditary diffuse gastric carcinoma.

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14.

Grady WM et. al. (2000) Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer.

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15.

Caldas C et al. (1999) Familial gastric cancer: overview and guidelines for management.

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16.

Guilford PJ et. al. (1999) E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer.

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17.

Kakiuchi H et al. () Familial gastric cancer in the Japanese population is frequently located at the cardiac region.

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18.

Richards FM et. al. (1999) Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer.

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19.

Gayther SA et. al. (1998) Identification of germ-line E-cadherin mutations in gastric cancer families of European origin.

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20.

Guilford P et. al. (1998) E-cadherin germline mutations in familial gastric cancer.

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21.

Carneiro F et. al. (1995) New elements for an updated classification of the carcinomas of the stomach.

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