In some carcinoid tumors of lung somatic mutations of the MEN1 gene can be found.
1. |
Wautot V et al. (2002) Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein. |
2. |
Kjellman M et al. (1999) Genotyping of adrenocortical tumors: very frequent deletions of the MEN1 locus in 11q13 and of a 1-centimorgan region in 2p16. |
4. |
Cebrián A et al. (1999) Genetic and clinical analysis in 10 Spanish patients with multiple endocrine neoplasia type 1. |
5. |
Schulte KM et al. (1999) MEN I gene mutations in sporadic adrenal adenomas. |
6. |
Tahara H et al. (2000) Rare somatic inactivation of the multiple endocrine neoplasia type 1 gene in secondary hyperparathyroidism of uremia. |
7. |
Stratakis CA et al. (2000) Pituitary macroadenoma in a 5-year-old: an early expression of multiple endocrine neoplasia type 1. |
8. |
Crabtree JS et al. (2001) A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. |
9. |
Kaji H et al. (2001) Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling. |
10. |
Pannett AA et al. (2001) Somatic mutations in MEN type 1 tumors, consistent with the Knudson "two-hit" hypothesis. |
11. |
Guo SS et al. (2001) Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia type-1. |
13. |
Turner JJ et al. (2002) Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1. |
14. |
Agarwal SK et al. (1999) Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. |
15. |
Okamoto H et al. (2002) A novel six-nucleotide insertion in exon 4 of the MEN1 gene, 878insCTGCAG, in three patients with familial insulinoma and primary hyperparathyroidism. |
16. |
Park JH et al. (2003) Germline mutations of the MEN1 gene in Korean families with multiple endocrine neoplasia type 1 (MEN1) or MEN1-related disorders. |
17. |
Zablewska B et al. (2003) Transcription regulation of the multiple endocrine neoplasia type 1 gene in human and mouse. |
18. |
Balogh K et al. (2004) Unusual presentation of multiple endocrine neoplasia type 1 in a young woman with a novel mutation of the MEN1 gene. |
19. |
Ebeling T et al. (2004) Effect of multiple endocrine neoplasia type 1 (MEN1) gene mutations on premature mortality in familial MEN1 syndrome with founder mutations. |
20. |
Carrasco CA et al. (2004) Novel intronic mutation of MEN1 gene causing familial isolated primary hyperparathyroidism. |
21. |
Busygina V et al. (2004) Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1. |
22. |
Yokoyama A et al. (2005) The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. |
23. |
Chen YX et al. (2006) The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. |
25. |
Huang J et al. (2012) The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. |
26. |
Guru SC et al. (1998) Menin, the product of the MEN1 gene, is a nuclear protein. |
27. |
Jiao Y et al. (2011) DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. |
28. |
Lin SY et al. (2003) Multiple tumor suppressor pathways negatively regulate telomerase. |
29. |
Bear JC et al. (1985) Variant multiple endocrine neoplasia I (MEN IBurin): further studies and non-linkage to HLA. |
30. |
Farid NR et al. (1980) Prolactinomas in familial multiple endocrine neoplasia syndrome type I. Relationship to HLA and carcinoid tumors. |
31. |
Chandrasekharappa SC et al. (1997) Positional cloning of the gene for multiple endocrine neoplasia-type 1. |
32. |
Agarwal SK et al. (1997) Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. |
33. |
Lemmens I et al. (1997) Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. |
34. |
Darling TN et al. (1997) Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1. |
35. |
Heppner C et al. (1997) Somatic mutation of the MEN1 gene in parathyroid tumours. |
36. |
Debelenko LV et al. (1997) Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. |
37. |
Bassett JH et al. (1998) Characterization of mutations in patients with multiple endocrine neoplasia type 1. |
39. |
Vortmeyer AO et al. (1998) Multiple endocrine neoplasia 1 gene alterations in MEN1-associated and sporadic lipomas. |
40. |
Prezant TR et al. (1998) Molecular characterization of the men1 tumor suppressor gene in sporadic pituitary tumors. |
41. |
Olufemi SE et al. (1998) Common ancestral mutation in the MEN1 gene is likely responsible for the prolactinoma variant of MEN1 (MEN1Burin) in four kindreds from Newfoundland. |
42. |
Giraud S et al. (1998) Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders. |
43. |
Teh BT et al. (1998) Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism. |
44. |
Farnebo F et al. (1998) Alterations of the MEN1 gene in sporadic parathyroid tumors. |
45. |
Carling T et al. (1998) Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism. |
46. |
Böni R et al. (1998) Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic angiofibromas. |
47. |
Teh BT et al. (1998) A family with isolated hyperparathyroidism segregating a missense MEN1 mutation and showing loss of the wild-type alleles in the parathyroid tumors. |
48. |
Fujimori M et al. (1998) Novel V184E MEN1 germline mutation in a Japanese kindred with familial hyperparathyroidism. |
49. |
Heppner C et al. (1999) MEN1 gene analysis in sporadic adrenocortical neoplasms. |