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Center for Nephrology and Metabolic Disorders
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Non-Hodgkin lymphoma

Non-Hodgkin lymphoma is a malign hematological disorder characterized by abundant proliferation of lymphoid organs. In some cases somatic mutations of the CASP10 gene are the reason.

Systematic

Hereditary malign blood disorders
Acute myeloid leukemia
Juvenile myelomonocytic leukemia
Lymphoproliferative syndrome
Myelodysplastic syndrome
Myelofibrosis
Non-Hodgkin lymphoma
CASP10
Noonan syndrome-like disorder and juvenile myelomonocytic leukemia
Polycythemia vera
Somatic erythrocytosis
Susceptibility to acute myeloid leukemia
Susceptibility to myelodysplastic syndrome

References:

1.

Clementi R et al. (2005) A proportion of patients with lymphoma may harbor mutations of the perforin gene.

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2.

Compagno M et al. (2009) Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.

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3.

Morin RD et al. (2011) Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.

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4.

Wiernik PH et al. (2000) Age of onset evidence for anticipation in familial non-Hodgkin's lymphoma.

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5.

Altieri A et al. (2005) Familial risk for non-Hodgkin lymphoma and other lymphoproliferative malignancies by histopathologic subtype: the Swedish Family-Cancer Database.

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6.

Lenz G et al. (2008) Oncogenic CARD11 mutations in human diffuse large B cell lymphoma.

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7.

Davis RE et al. (2010) Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.

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8.

Morin RD et al. (2010) Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

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9.

Pasqualucci L et al. (2011) Inactivating mutations of acetyltransferase genes in B-cell lymphoma.

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10.

Scuoppo C et al. (2012) A tumour suppressor network relying on the polyamine-hypusine axis.

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Update: Aug. 14, 2020
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