Psoriasis is quite heritable. It is associated with various loci throughout the genome. The type 1 susceptibility is associates with HLA-C, the HLA-Cw6 allele in particular.
1. |
Balendran N et al. (1999) Characterization of the major susceptibility region for psoriasis at chromosome 6p21.3. |
2. |
Asumalahti K et al. (2002) Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus. |
4. |
Gudjónsson JE et al. (2002) HLA-Cw6-positive and HLA-Cw6-negative patients with Psoriasis vulgaris have distinct clinical features. |
5. |
Schmitt-Egenolf M et al. (2001) Comparative association analysis reveals that corneodesmosin is more closely associated with psoriasis than HLA-Cw*0602-B*5701 in German families. |
6. |
O'Brien KP et al. (2001) The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene. |
7. |
Mallon E et al. (2000) HLA-C and guttate psoriasis. |
8. |
Gonzalez S et al. (2000) The OTF3 gene polymorphism confers susceptibility to psoriasis independent of the association of HLA-Cw*0602. |
9. |
Asumalahti K et al. (2000) A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. |
10. |
Nair RP et al. (2000) Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C. |
11. |
Oka A et al. (1999) Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene. |
12. |
Veal CD et al. (2002) Family-based analysis using a dense single-nucleotide polymorphism-based map defines genetic variation at PSORS1, the major psoriasis-susceptibility locus. |
13. |
Tazi Ahnini R et al. (1999) Novel genetic association between the corneodesmosin (MHC S) gene and susceptibility to psoriasis. |
14. |
Leder RO et al. (1999) Psoriasis linkage in the HLA region. |
15. |
Leder RO et al. () Familial psoriasis and HLA-B: unambiguous support for linkage in 97 published families. |
17. |
Burden AD et al. (1998) Genetics of psoriasis: paternal inheritance and a locus on chromosome 6p. |
18. |
Swanbeck G et al. (1997) Genetic counselling in psoriasis: empirical data on psoriasis among first-degree relatives of 3095 psoriatic probands. |
19. |
Trembath RC et al. (1997) Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis. |
21. |
Chen ML et al. (1996) Induction of vitamin D receptor mRNA expression in psoriatic plaques correlates with clinical response to 1,25-dihydroxyvitamin D3. |
22. |
Lowes MA et al. (2005) Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). |
23. |
Kopp T et al. (2015) Clinical improvement in psoriasis with specific targeting of interleukin-23. |
24. |
Tonel G et al. (2010) Cutting edge: A critical functional role for IL-23 in psoriasis. |
25. |
et al. (2010) A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. |
26. |
Nestle FO et al. (2009) Psoriasis. |
27. |
Li Y et al. (2009) Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22. |
28. |
Hollox EJ et al. (2008) Psoriasis is associated with increased beta-defensin genomic copy number. |
29. |
Lande R et al. (2007) Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. |
30. |
Conrad C et al. (2007) Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. |
31. |
Krueger GG et al. (2007) A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. |
32. |
Rosbotham JL et al. (1994) An association between psoriasis and hereditary multiple exostoses. A clue for the mapping of a psoriasis susceptibility gene? |
33. |
Helms C et al. (2005) Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR. |
34. |
Orrù S et al. (2005) Mapping of the major psoriasis-susceptibility locus (PSORS1) in a 70-Kb interval around the corneodesmosin gene (CDSN). |
35. |
Elomaa O et al. (2004) Transgenic mouse models support HCR as an effector gene in the PSORS1 locus. |
36. |
STEINBERG AG et al. (1951) A genetic and statistical study of psoriasis. |
37. |
ABELE DC et al. (1963) HEREDITY AND PSORIASIS. STUDY OF A LARGE FAMILY. |
38. |
WARD JH et al. (1961) Inheritance of psoriasis in a Utah kindred. |
39. |
STEINBERG AG et al. (1952) A further note on the genetics of psoriasis. |
40. |
Asumalahti K et al. (2003) Genetic analysis of PSORS1 distinguishes guttate psoriasis and palmoplantar pustulosis. |
41. |
Gudjonsson JE et al. (2003) Psoriasis patients who are homozygous for the HLA-Cw*0602 allele have a 2.5-fold increased risk of developing psoriasis compared with Cw6 heterozygotes. |
42. |
Nair RP et al. (1997) Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan. |
43. |
None (2003) The International Psoriasis Genetics Study: assessing linkage to 14 candidate susceptibility loci in a cohort of 942 affected sib pairs. |
44. |
Veal CD et al. (2001) Identification of a novel psoriasis susceptibility locus at 1p and evidence of epistasis between PSORS1 and candidate loci. |
45. |
Hüffmeier U et al. (2009) Characterisation of psoriasis susceptibility locus 6 (PSORS6) in patients with early onset psoriasis and evidence for interaction with PSORS1. |
46. |
Caruso R et al. (2009) Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. |
47. |
Matthews D et al. (1996) Evidence that a locus for familial psoriasis maps to chromosome 4q. |
48. |
Zenz R et al. (2005) Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. |
49. |
Capon F et al. (1999) Evidence for interaction between psoriasis-susceptibility loci on chromosomes 6p21 and 1q21. |
51. |
Park BS et al. (1999) Vitamin D receptor polymorphism is associated with psoriasis. |
52. |
Jordan CT et al. (2012) Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. |
53. |
Zhang XJ et al. (2002) Evidence for a major psoriasis susceptibility locus at 6p21(PSORS1) and a novel candidate region at 4q31 by genome-wide scan in Chinese hans. |
54. |
Sugiura K et al. (2013) The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist. |
55. |
Setta-Kaffetzi N et al. (2013) Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes. |
56. |
Marrakchi S et al. (2011) Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis. |
57. |
Boyman O et al. (2004) Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha. |
58. |
Ghoreschi K et al. (2003) Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease. |
59. |
Nair RP et al. (2006) Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. |
60. |
Asadullah K et al. (2001) Interleukin-10 promoter polymorphism in psoriasis. |
61. |
Abrams JR et al. (1999) CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. |
62. |
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63. |
Farber EM et al. (1974) Natural history of psoriasis in 61 twin pairs. |
64. |
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66. |
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67. |
Burch PR et al. (1981) Mode of inheritance in psoriasis. |
68. |
Pietrzyk JJ et al. (1982) Family studies in psoriasis. I. Complex segregation analysis. |
69. |
Brandrup F et al. (1982) Psoriasis in monozygotic twins: variations in expression in individuals with identical genetic constitution. |
70. |
Watson W et al. (1972) The genetics of psoriasis. |
71. |
White SH et al. (1972) Disturbance of HL-A antigen frequency in Psoriasis. |
72. |
Russell TJ et al. (1972) Histocompatibility (HL-A) antigens associated with psoriasis. |
73. |
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74. |
Moll JM et al. (1973) Familial occurrence of psoriatic arthritis. |
75. |
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76. |
Kimberling W et al. (1973) The inheritance of psoriasis. |
77. |
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78. |
Propping P et al. (1985) Increased birth weight in psoriasis--another expression of a "thrifty genotype"? |
79. |
Saiag P et al. (1985) Psoriatic fibroblasts induce hyperproliferation of normal keratinocytes in a skin equivalent model in vitro. |
80. |
Suarez-Almazor ME et al. (1990) The genetics of psoriasis. Haplotype sharing in siblings with the disease. |
81. |
None (1991) Somatic recombination may explain linear psoriasis. |
82. |
Chang EY et al. (1992) T-cell activation is potentiated by cytokines released by lesional psoriatic, but not normal, epidermis. |