Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
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Psoriasis susceptibility 1

Psoriasis is quite heritable. It is associated with various loci throughout the genome. The type 1 susceptibility is associates with HLA-C, the HLA-Cw6 allele in particular.

Systematic

Psoriasis
CARD14 associated psoriasis
Psoriasis 14
Psoriasis 15
Psoriasis susceptibility 1
HLA-C
Psoriasis susceptibility 10
Psoriasis susceptibility 11
Psoriasis susceptibility 12
Psoriasis susceptibility 13
Psoriasis susceptibility 3
Psoriasis susceptibility 4
Psoriasis susceptibility 5
Psoriasis susceptibility 6
Psoriasis susceptibility 7
Psoriasis susceptibility 8
Psoriasis susceptibility 9

References:

1.

Balendran N et al. (1999) Characterization of the major susceptibility region for psoriasis at chromosome 6p21.3.

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2.

Asumalahti K et al. (2002) Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus.

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3.

Reich K et al. (2002) Promoter polymorphisms of the genes encoding tumor necrosis factor-alpha and interleukin-1beta are associated with different subtypes of psoriasis characterized by early and late disease onset.

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4.

Gudjónsson JE et al. (2002) HLA-Cw6-positive and HLA-Cw6-negative patients with Psoriasis vulgaris have distinct clinical features.

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5.

Schmitt-Egenolf M et al. (2001) Comparative association analysis reveals that corneodesmosin is more closely associated with psoriasis than HLA-Cw*0602-B*5701 in German families.

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6.

O'Brien KP et al. (2001) The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene.

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7.

Mallon E et al. (2000) HLA-C and guttate psoriasis.

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8.

Gonzalez S et al. (2000) The OTF3 gene polymorphism confers susceptibility to psoriasis independent of the association of HLA-Cw*0602.

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9.

Asumalahti K et al. (2000) A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele.

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10.

Nair RP et al. (2000) Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C.

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11.

Oka A et al. (1999) Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene.

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12.

Veal CD et al. (2002) Family-based analysis using a dense single-nucleotide polymorphism-based map defines genetic variation at PSORS1, the major psoriasis-susceptibility locus.

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13.

Tazi Ahnini R et al. (1999) Novel genetic association between the corneodesmosin (MHC S) gene and susceptibility to psoriasis.

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14.

Leder RO et al. (1999) Psoriasis linkage in the HLA region.

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15.

Leder RO et al. () Familial psoriasis and HLA-B: unambiguous support for linkage in 97 published families.

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16.

Jenisch S et al. (1998) Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region.

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17.

Burden AD et al. (1998) Genetics of psoriasis: paternal inheritance and a locus on chromosome 6p.

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18.

Swanbeck G et al. (1997) Genetic counselling in psoriasis: empirical data on psoriasis among first-degree relatives of 3095 psoriatic probands.

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19.

Trembath RC et al. (1997) Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis.

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20.

Schmitt-Egenolf M et al. (1996) Familial juvenile onset psoriasis is associated with the human leukocyte antigen (HLA) class I side of the extended haplotype Cw6-B57-DRB1*0701-DQA1*0201-DQB1*0303: a population- and family-based study.

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21.

Chen ML et al. (1996) Induction of vitamin D receptor mRNA expression in psoriatic plaques correlates with clinical response to 1,25-dihydroxyvitamin D3.

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22.

Lowes MA et al. (2005) Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a).

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23.

Kopp T et al. (2015) Clinical improvement in psoriasis with specific targeting of interleukin-23.

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24.

Tonel G et al. (2010) Cutting edge: A critical functional role for IL-23 in psoriasis.

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25.

et al. (2010) A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

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26.

Nestle FO et al. (2009) Psoriasis.

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27.

Li Y et al. (2009) Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22.

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28.

Hollox EJ et al. (2008) Psoriasis is associated with increased beta-defensin genomic copy number.

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29.

Lande R et al. (2007) Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.

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30.

Conrad C et al. (2007) Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.

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31.

Krueger GG et al. (2007) A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis.

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32.

Rosbotham JL et al. (1994) An association between psoriasis and hereditary multiple exostoses. A clue for the mapping of a psoriasis susceptibility gene?

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33.

Helms C et al. (2005) Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.

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34.

Orrù S et al. (2005) Mapping of the major psoriasis-susceptibility locus (PSORS1) in a 70-Kb interval around the corneodesmosin gene (CDSN).

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35.

Elomaa O et al. (2004) Transgenic mouse models support HCR as an effector gene in the PSORS1 locus.

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36.

STEINBERG AG et al. (1951) A genetic and statistical study of psoriasis.

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37.

ABELE DC et al. (1963) HEREDITY AND PSORIASIS. STUDY OF A LARGE FAMILY.

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38.

WARD JH et al. (1961) Inheritance of psoriasis in a Utah kindred.

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39.

STEINBERG AG et al. (1952) A further note on the genetics of psoriasis.

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40.

Asumalahti K et al. (2003) Genetic analysis of PSORS1 distinguishes guttate psoriasis and palmoplantar pustulosis.

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41.

Gudjonsson JE et al. (2003) Psoriasis patients who are homozygous for the HLA-Cw*0602 allele have a 2.5-fold increased risk of developing psoriasis compared with Cw6 heterozygotes.

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42.

Nair RP et al. (1997) Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan.

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43.

None (2003) The International Psoriasis Genetics Study: assessing linkage to 14 candidate susceptibility loci in a cohort of 942 affected sib pairs.

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44.

Veal CD et al. (2001) Identification of a novel psoriasis susceptibility locus at 1p and evidence of epistasis between PSORS1 and candidate loci.

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45.

Hüffmeier U et al. (2009) Characterisation of psoriasis susceptibility locus 6 (PSORS6) in patients with early onset psoriasis and evidence for interaction with PSORS1.

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46.

Caruso R et al. (2009) Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis.

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47.

Matthews D et al. (1996) Evidence that a locus for familial psoriasis maps to chromosome 4q.

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48.

Zenz R et al. (2005) Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins.

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49.

Capon F et al. (1999) Evidence for interaction between psoriasis-susceptibility loci on chromosomes 6p21 and 1q21.

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50.

Enlund F et al. (1999) Analysis of three suggested psoriasis susceptibility loci in a large Swedish set of families: confirmation of linkage to chromosome 6p (HLA region), and to 17q, but not to 4q.

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51.

Park BS et al. (1999) Vitamin D receptor polymorphism is associated with psoriasis.

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52.

Jordan CT et al. (2012) Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis.

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53.

Zhang XJ et al. (2002) Evidence for a major psoriasis susceptibility locus at 6p21(PSORS1) and a novel candidate region at 4q31 by genome-wide scan in Chinese hans.

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54.

Sugiura K et al. (2013) The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist.

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55.

Setta-Kaffetzi N et al. (2013) Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes.

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56.

Marrakchi S et al. (2011) Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.

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57.

Boyman O et al. (2004) Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha.

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58.

Ghoreschi K et al. (2003) Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease.

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59.

Nair RP et al. (2006) Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.

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60.

Asadullah K et al. (2001) Interleukin-10 promoter polymorphism in psoriasis.

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61.

Abrams JR et al. (1999) CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris.

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62.

Sayegh MH et al. (1998) The role of T-cell costimulatory activation pathways in transplant rejection.

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63.

Farber EM et al. (1974) Natural history of psoriasis in 61 twin pairs.

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64.

Swanbeck G et al. (1994) A population genetic study of psoriasis.

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65.

Bata-Csorgo Z et al. (1995) Kinetics and regulation of human keratinocyte stem cell growth in short-term primary ex vivo culture. Cooperative growth factors from psoriatic lesional T lymphocytes stimulate proliferation among psoriatic uninvolved, but not normal, stem keratinocytes.

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66.

Tiilikainen A et al. (1980) Psoriasis and HLA-Cw6.

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67.

Burch PR et al. (1981) Mode of inheritance in psoriasis.

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68.

Pietrzyk JJ et al. (1982) Family studies in psoriasis. I. Complex segregation analysis.

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69.

Brandrup F et al. (1982) Psoriasis in monozygotic twins: variations in expression in individuals with identical genetic constitution.

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70.

Watson W et al. (1972) The genetics of psoriasis.

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71.

White SH et al. (1972) Disturbance of HL-A antigen frequency in Psoriasis.

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72.

Russell TJ et al. (1972) Histocompatibility (HL-A) antigens associated with psoriasis.

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73.

Reiser H et al. (1996) Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases.

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74.

Moll JM et al. (1973) Familial occurrence of psoriatic arthritis.

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75.

Beckman L et al. (1974) HL-A antigens, blood groups, serum groups and red cell enzyme thypes in psoriasis.

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76.

Kimberling W et al. (1973) The inheritance of psoriasis.

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77.

Burch PR et al. (1965) Psoriasis: aetiological aspects.

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78.

Propping P et al. (1985) Increased birth weight in psoriasis--another expression of a "thrifty genotype"?

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79.

Saiag P et al. (1985) Psoriatic fibroblasts induce hyperproliferation of normal keratinocytes in a skin equivalent model in vitro.

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80.

Suarez-Almazor ME et al. (1990) The genetics of psoriasis. Haplotype sharing in siblings with the disease.

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81.

None (1991) Somatic recombination may explain linear psoriasis.

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82.

Chang EY et al. (1992) T-cell activation is potentiated by cytokines released by lesional psoriatic, but not normal, epidermis.

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Update: Aug. 14, 2020
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