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Disturbances of cytochrome p450 system

The cytochrome p450 system is an important enzyme system of drug metabolism, so it comes as no suprise that interferences in common metabolic pathways result in drug interactions and intolerance.

Systematic

Genetic alterations of drug tolerance
Coumarin resistance
Disturbances of cytochrome p450 system
CYP1A2
CYP2A6
CYP2C9
CYP2D6
CYP3A4
CYP4F2
Siponimod intolerance
CYP2C9
Hepatitis C response to therapy
PPI-induced Hypomagnesemia

References:

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58.

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59.

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60.

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62.

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65.

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70.

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79.

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80.

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81.

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84.

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85.

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87.

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88.

Matsunaga E et al. (1989) The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats.

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89.

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93.

Gonzalez FJ et al. (1987) Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.

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94.

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95.

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96.

Nebert DW et al. (1987) The P450 gene superfamily: recommended nomenclature.

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97.

Eichelbaum M et al. (1985) Inter-ethnic difference in sparteine oxidation among Ghanaians and Germans.

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98.

Distlerath LM et al. (1984) Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme.

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99.

Dahl ML et al. (1995) Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

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100.

Agúndez JA et al. (1995) Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population.

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101.

Mura C et al. (1993) DNA haplotype dependency of debrisoquine 4-hydroxylase (CYP2D6) expression among extensive metabolisers.

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102.

Johansson I et al. (1994) Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

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103.

Bertilsson L et al. (1993) Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine.

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104.

Gough AC et al. (1993) Localization of the CYP2D gene locus to human chromosome 22q13.1 by polymerase chain reaction, in situ hybridization, and linkage analysis.

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105.

Daly AK et al. (1996) Nomenclature for human CYP2D6 alleles.

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106.

Nelson DR et al. (1996) P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

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107.

None (1997) Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?

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108.

Sachse C et al. (1997) Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

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109.

McLellan RA et al. (1997) Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians.

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110.

Tyndale RF et al. (1997) Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence.

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111.

Mikus G et al. (1998) Relevance of deficient CYP2D6 in opiate dependence.

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112.

Lundqvist E et al. (1999) Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes.

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113.

Bathum L et al. (1998) Ultrarapid metabolism of sparteine: frequency of alleles with duplicated CYP2D6 genes in a Danish population as determined by restriction fragment length polymorphism and long polymerase chain reaction.

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114.

Tateishi T et al. (1999) Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population.

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115.

Brown MA et al. (2000) Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis.

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116.

Payami H et al. (2001) Parkinson's disease, CYP2D6 polymorphism, and age.

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117.

Elbaz A et al. (2004) CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease.

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118.

Deng Y et al. (2004) Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease.

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119.

Liou YH et al. (2006) The high prevalence of the poor and ultrarapid metabolite alleles of CYP2D6, CYP2C9, CYP2C19, CYP3A4, and CYP3A5 in Taiwanese population.

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120.

Pilotto A et al. (2009) Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease.

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121.

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