Protein kinase, lysin-deficient 1
The WNK1 gene encodes a cytoplasmic serine-threonine kinase that plays an important role in signal transduction in the distal nephron. Mutations that cause an activation result in pseudohypoaldosteronism type 2 whereas loss-of-function mutations cause a hereditary sensory and autonomic neuropathy.
Cope G et al. (2005) WNK kinases and the control of blood pressure.
Hadchouel J et al. (2006) Familial hyperkalemic hypertension.
Subramanya AR et al. (2006) WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron.
Update: Sept. 26, 2018