This gene is intensly researched into its contribution to diabetic complications. Several genetic variations have been associated with diabetic nephropathy.
Wolford JK et al. (2006) Variants in the gene encoding aldose reductase (AKR1B1) and diabetic nephropathy in American Indians.
Graham A et al. (1991) Structure of the human aldose reductase gene.
Shah VO et al. (1997) Aldose reductase gene expression is increased in diabetic nephropathy.
Update: Sept. 26, 2018