Angiotensin converting enzyme 2
This is a new emerging candidate gene responsible for hypertension.
The gene exhibits 60% sequence similarity to ACE.
The enzyme seems to be an important element of tissue renin-agiotensin system. To the moment it has been found in murine heart and kidneys.
In three distinct models of hypertension, reduced expression of the protein in the kidney correlated with blood pressure. Still, there are not known human diseases caused by mutations of ACE2.
The catalytic activity of ACE2 is excerted by cleavage of a single amino acid residue at the carboxyl terminus. The physiological role is conversion of angiotensin II to angiotensin-(1-7). The enzyme is resistant to ACE inhibitors.
|Research||Method||Genomic sequencing of the entire coding region|
|Specimen type||genomic DNA|
Chappel MC et al. (2006) ACE and ACE2: their role to balance the expression of angiotensin II and angiotensin-(1-7).[^]
NCBI articleNCBI 59272 [^]
OMIM.ORG articleOmim 300335 [^]
Wikipedia articleWikipedia EN (Angiotensin-converting_enzyme_2) [^]