Epidermal growth factor receptor
The gene encodes the receptor of the epidermal growth factor. Mutations can be found in nonsmall cell lung cancer and appear to influence responsiveness to tyrosine kinase inhibitors. A role in regulation of the magnesium channel TRPM6 has also been demonstrated, so it influences magnesium homeostasis.
Groenestege WM et al. (2007) Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia.
Tejpar S et al. (2007) Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study.
Update: Sept. 26, 2018