Epidermal growth factor receptor

The gene encodes the receptor of the epidermal growth factor. Mutations can be found in nonsmall cell lung cancer and appear to influence responsiveness to tyrosine kinase inhibitors. A role in regulation of the magnesium channel TRPM6 has also been demonstrated, so it influences magnesium homeostasis.

Genetests:

Related Diseases:

Hypomagnesemia
	EGFR
	Gitelman syndrome
		SLC12A3
	Hereditary myokymia type 1
		KCNA1
	Hypomagnesemia with hypercalciuria and nephrocalcinosis
		CLDN16
	Hypomagnesemia with hypercalciuria and nephrocalcinosis with ocular involvement
		CLDN19
	Hypomagnesemia with normocalciuria
		EGF
	Intestinal hypomagnesemia with secondary hypocalcemia
		TRPM6
	Isolated dominant hypomagnesemia
		FXYD2
	PPI-induced Hypomagnesemia
		TRPM6
	Renal cysts and diabetes (RCAD)
		HNF1B
	Renal hypomagnesemia 6
		CNNM2
	TRPM7

References:

1.	Groenestege WM et al. (2007) Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia.

2.	Tejpar S et al. (2007) Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study.

3.	Orphanet article Orphanet ID 121311

4.	NCBI article NCBI 1956

5.	OMIM.ORG article Omim 131550

6.	Wikipedia article Wikipedia EN (Epidermal_growth_factor_receptor)