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Transient receptor potential cation channel, subfamily M, member 7

This TRPM7 gene resembles TRPM6 in its ability to channel divalent cations including magnesium, so it might play a role magnesium homeostasis. Genetic variations are associated with amyotrophic lateral sclerosis, too.

Genetests:

Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Hypomagnesemia
EGFR
Gitelman syndrome
SLC12A3
Hereditary myokymia type 1
KCNA1
Hypomagnesemia with hypercalciuria and nephrocalcinosis
CLDN16
Hypomagnesemia with hypercalciuria and nephrocalcinosis with ocular involvement
CLDN19
Hypomagnesemia with normocalciuria
EGF
Intestinal hypomagnesemia with secondary hypocalcemia
TRPM6
Isolated dominant hypomagnesemia
FXYD2
Renal cysts and diabetes (RCAD)
HNF1B
Renal hypomagnesemia 6
CNNM2
TRPM7

References:

1.

Schmitz C et al. (2005) The channel kinases TRPM6 and TRPM7 are functionally nonredundant.

external link
2.

Li M et al. (2006) Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.

external link
3.

Schlingmann KP et al. (2007) TRPM6 and TRPM7--Gatekeepers of human magnesium metabolism.

external link
4.

Li M et al. (2007) Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7.

external link
5.

OMIM.ORG article

Omim 605692 external link
6.

Orphanet article

Orphanet ID 159298 external link
7.

NCBI article

NCBI 54822 external link
8.

Wikipedia article

Wikipedia EN (TRPM7) external link
Update: Aug. 14, 2020
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