Complement factor H-related 2
This is one of 5 complement factor H-related genes that occur in tandem with CFH. All these genes though less transcribed share some structural domains and functional properties with complement factor H. Some mutations and polymorphisms have been associated with atypical HUS and age-related macula degeneration.
Nürnberger J et al. (2009) Eculizumab for atypical hemolytic-uremic syndrome.
Zhang H et al. (2008) The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.
NCBI 3080 [^]
Omim 600889 [^]
Wikipedia EN (CFHR2) [^]
Update: April 29, 2019