V-KI-RAS2 Kirsten rat sarcoma viral oncogene homolog
The KRAS gene encodes an importent protein in signal transduction. In 17-25% of human tumor cells a somatic activating mutation can be found. These mutations make make the cell resistant to GTPase activating peptides.
Ahrendt SA et al. (2001) Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.
Andreyev HJ et al. (1997) K-ras mutations in patients with early colorectal cancers.
Update: Sept. 26, 2018