Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

V-KI-RAS2 Kirsten rat sarcoma viral oncogene homolog

The KRAS gene encodes an importent protein in signal transduction. In 17-25% of human tumor cells a somatic activating mutation can be found. These mutations make make the cell resistant to GTPase activating peptides.

Genetests:

Research Method Multiplex Ligation-Dependent Probe Amplification
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 20 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

References:

1.

Ahrendt SA et al. (2001) Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.

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2.

Andreyev HJ et al. (1997) K-ras mutations in patients with early colorectal cancers.

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Update: Sept. 26, 2018