Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

V-KI-RAS2 Kirsten rat sarcoma viral oncogene homolog

The KRAS gene encodes an importent protein in signal transduction. In 17-25% of human tumor cells a somatic activating mutation can be found. These mutations make make the cell resistant to GTPase activating peptides.

Genetests:

Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 20 days
Specimen type genomic DNA
Research Method Multiplex Ligation-Dependent Probe Amplification
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

References:

1.

Ahrendt SA et al. (2001) Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.

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2.

Andreyev HJ et al. (1997) K-ras mutations in patients with early colorectal cancers.

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3.

NCBI article

NCBI 3845 [^]
4.

OMIM.ORG article

Omim 190070 [^]
5.

Orphanet article

Orphanet ID 122879 [^]
6.

Wikipedia article

Wikipedia EN (KRAS) [^]
Update: April 29, 2019