The gene product of NEUROD1 plays a role as a transcription factor in insulin secretion of beta cells by binding to its promotor's E-box. Mutations cause autosomal dominant diabetes MODY6.
Fajans SS et al. (2001) Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.
Malecki MT et al. (1999) Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus.
Orphanet ID 123762
Wikipedia EN (NEUROD1)
Update: Aug. 14, 2020