Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Transcriptionfactor KLF11

The gene KLF11 encodes a zinc finger transcription factor involved in regulation of insulin secretetion. Missensemutations in this gene might cause autosomal dominant MODY7 diabetes.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Multiplex Ligation-Dependent Probe Amplification
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

MODY7 diabetes
KLF11

References:

1.

Neve B et al. (2005) Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.

external link
2.

NCBI article

NCBI 8462 external link
3.

OMIM.ORG article

Omim 603301 external link
4.

Orphanet article

Orphanet ID 122868 external link
5.

Wikipedia article

Wikipedia EN (KLF11) external link
Update: Aug. 14, 2020
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