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Center for Nephrology and Metabolic Disorders
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Renin

Renin catalyzes angiotensin activation and by that token plays an important role in blood pressure and electrolyte balance. During ontogenesis ist has an imprtant funktion in regulation of kidney development. Mutation account for autosomal recessive or dominant disorders of blood pressure regulation or renal malformations.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Benign hyperproreninemia
REN
Renal tubular dysgenesis
ACE
AGT
AGTR1
REN
Hyperuricemic nephropathy, familial juvenile 2
REN
Autosomal dominant tubulointerstitial kidney disease (ADTKD)
HNF1B
MUC1
REN
SEC61A1
UMOD

References:

1.

Hobart PM et al. (1984) Human renin gene: structure and sequence analysis.

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2.

Pratt RE et al. (1988) Different secretory pathways of renin from mouse cells transfected with the human renin gene.

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3.

Masharani U et al. (1988) MboI RFLP at the human renin (ren) gene locus.

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4.

Nakai H et al. (1988) Human renin gene assigned to chromosome band 1q42 by in situ hybridization.

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5.

McGill JR et al. (1987) Chromosome localization of the human renin gene (REN) by in situ hybridization.

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6.

Griffiths LR et al. (1987) Regional chromosomal assignment of human renin gene to 1q12----qter and use in linkage studies in Charcot-Marie-Tooth disease.

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7.

Frossard PM et al. (1986) Two RFLPs at the human renin (ren) gene locus.

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8.

Fritz LC et al. (1986) Characterization of human prorenin expressed in mammalian cells from cloned cDNA.

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9.

Field LJ et al. (1985) Ren-1 and Ren-2 loci are expressed in mouse kidney.

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10.

Youssoufian H et al. (1988) Association of a new chromosomal deletion [del(1)(q32q42)] with diaphragmatic hernia: assignment of a human ferritin gene.

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11.

Miyazaki H et al. (1984) Structure of the human renin gene.

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12.

Chirgwin JM et al. (1984) Mouse kidney renin gene is on chromosome one.

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13.

Imai T et al. (1983) Cloning and sequence analysis of cDNA for human renin precursor.

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14.

Hardman JA et al. (1984) Primary structure of the human renin gene.

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15.

Qin H et al. () Reassignment of human renin gene to chromosome 1q32 in studies of a (1;4)(q42;p16) translocation.

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16.

Peters J et al. (1993) Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II, and calcium.

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17.

None (1993) Transgenic models of hypertension: useful tools or unusual toys?

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18.

Abel KJ et al. (1988) Close physical linkage of the murine Ren-1 and Ren-2 loci.

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19.

Gribouval O et al. (2005) Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.

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20.

Stibůrková B et al. (2003) Familial juvenile hyperuricaemic nephropathy (FJHN): linkage analysis in 15 families, physical and transcriptional characterisation of the FJHN critical region on chromosome 16p11.2 and the analysis of seven candidate genes.

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21.

Zivná M et al. (2009) Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure.

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22.

van Hooft IM et al. (1991) Renal hemodynamics and the renin-angiotensin-aldosterone system in normotensive subjects with hypertensive and normotensive parents.

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23.

Rapp JP et al. (1989) A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure.

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24.

Villard E et al. (1994) A mutant renin gene in familial elevation of prorenin.

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25.

Frossard PM et al. (1999) Human renin gene BglI dimorphism associated with hypertension in two independent populations.

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26.

Nguyen G et al. (2002) Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.

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27.

Jeunemaitre X et al. (1992) Sib pair linkage analysis of renin gene haplotypes in human essential hypertension.

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28.

Caron KM et al. (2004) Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene.

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29.

Pravenec M et al. (1991) The rat renin gene: assignment to chromosome 13 and linkage to the regulation of blood pressure.

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30.

Yokota H et al. (2007) Prorenin levels in retinopathy of prematurity.

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31.

Mullins JJ et al. (1990) Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene.

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32.

Rouleau GA et al. (1990) A genetic map of chromosome 1: comparison of different data sets and linkage programs.

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33.

Naftilan AJ et al. (1989) A lack of genetic linkage of renin gene restriction fragment length polymorphisms with human hypertension.

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34.

Morris BJ et al. (1988) Frequency in hypertensives of alleles for a RFLP associated with the renin gene.

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35.

OMIM.ORG article

Omim 179820 external link
36.

Orphanet article

Orphanet ID 138530 external link
37.

NCBI article

NCBI 5972 external link
38.

Wikipedia article

Wikipedia EN (Renin) external link
Update: Aug. 14, 2020
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