Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Angiotensin II receptor, type 1

The AGTR1 gene encodes the angiotensin receptor 1 which is involved in signal transduction regulation blood pressure and electrolyt balance. Also during kidney development the renin angiotensin system plays a role.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Renal tubular dysgenesis
ACE
AGT
AGTR1
REN

References:

1.

Gribouval O et al. (2005) Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.

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2.

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3.

Wallukat G et. al. (1999) Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.

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4.

Paradis P et al. (2000) Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling.

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5.

AbdAlla S et al. (2000) AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration.

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6.

Martin MM et al. (2001) Human angiotensin II type 1 receptor isoforms encoded by messenger RNA splice variants are functionally distinct.

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7.

Sasaki K et al. (2002) Evidence for the importance of angiotensin II type 1 receptor in ischemia-induced angiogenesis.

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8.

Mauzy CA et al. (1992) Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor.

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9.

Kobashi G et al. (2004) A1166C variant of angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy independently of T235 variant of angiotensinogen gene.

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10.

Curnow KM et al. (1992) Genetic analysis of the human type-1 angiotensin II receptor.

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11.

Chaves FJ et al. (2004) Polymorphisms of the renin-angiotensin system influence height in normotensive women in a Spanish population.

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12.

Furuta H et al. (1992) Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor.

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13.

Takayanagi R et al. (1992) Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.

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14.

AbdAlla S et al. (2004) Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis.

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15.

Bergsma DJ et al. (1992) Cloning and characterization of a human angiotensin II type 1 receptor.

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16.

Elton TS et al. (1992) Isolation of two distinct type I angiotensin II receptor genes.

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17.

Kuba K et al. (2005) A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.

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18.

Martin MM et al. (2006) MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts.

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19.

Gemmill RM et al. (1991) Report of the Second International Workshop on Human Chromosome 3 mapping.

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20.

Crowley SD et al. (2006) Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.

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21.

Martin MM et al. (2007) The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microrna-155 binding.

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22.

Billet S et al. (2007) Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice.

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23.

Sethupathy P et al. (2007) Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes.

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24.

Li H et al. (2008) Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells.

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25.

Sasaki K et al. (1991) Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor.

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26.

Murphy TJ et al. (1991) Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor.

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27.

Wilson GN et al. (1985) Further delineation of the dup(3q) syndrome.

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28.

Ito M et al. (1995) Regulation of blood pressure by the type 1A angiotensin II receptor gene.

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29.

Bonnardeaux A et. al. (1994) Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.

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30.

Konishi H et al. (1994) Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression.

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31.

Guo DF et al. (1994) The genomic organization of human angiotensin II type 1 receptor.

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32.

Mukoyama M et al. (1993) Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.

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33.

Kambayashi Y et al. (1993) Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.

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34.

Razdan K et al. (1996) Molecular cloning of a novel platelet protein showing homology to the angiotensin II receptor C-terminal domain.

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35.

Iyer SN et al. (1996) Chronic control of high blood pressure in the spontaneously hypertensive rat by delivery of angiotensin type 1 receptor antisense.

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36.

Haywood GA et al. (1997) AT1 and AT2 angiotensin receptor gene expression in human heart failure.

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37.

Wang WY et al. (1997) Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension.

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38.

Herzig TC et al. (1997) Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload.

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39.

Tsuchida S et al. (1998) Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.

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40.

Harada K et al. (1998) Angiotensin II type 1a receptor is involved in the occurrence of reperfusion arrhythmias.

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41.

Martens JR et al. (1998) Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy.

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42.

Oliverio MI et al. (1998) Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II.

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Update: Sept. 26, 2018