Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Phospholipase A2 receptor 1

The PLA2R1 gene encodes a secretory phospholipase. Autoantibodies angainst this protein were detected in membranous glomerulonephritis and polymorphisms in this gene show a strong correlation with idiopathic membranous nephropathy.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Membranous nephropathy
HLA-DQA1
PLA2R1

References:

1.

Beck LH et al. (2009) M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.

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2.

Ancian P et al. (1995) The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization.

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3.

Lv J et. al. (2013) Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy.

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4.

Debiec H et. al. (2014) Immunopathogenesis of membranous nephropathy: an update.

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5.

Smyth LJ et. al. (2014) Genetic and epigenetic factors influencing chronic kidney disease.

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6.

None (2015) Anti-phospholipase A2 Receptor Antibody and Immunosuppression in Membranous Nephropathy: More Evidence for Pathogenicity of Anti-phospholipase A2 Receptor Autoantibodies.

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7.

Lai WL et. al. (2015) Membranous nephropathy: a review on the pathogenesis, diagnosis, and treatment.

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8.

Li ZQ et. al. (2015) Efficacy and safety of tacrolimus vs. cyclophosphamide for idiopathic membranous nephropathy: A meta-analysis of Chinese adults.

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9.

Ronco P et. al. (2015) Membranous nephropathy: A fairy tale for immunopathologists, nephrologists and patients.

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10.

Ronco P et. al. (2015) Pathophysiological advances in membranous nephropathy: time for a shift in patient's care.

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11.

Ruggenenti P et. al. (2015) Anti-Phospholipase A2 Receptor Antibody Titer Predicts Post-Rituximab Outcome of Membranous Nephropathy.

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12.

Francis JM et. al. (2016) Membranous Nephropathy: A Journey From Bench to Bedside.

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13.

Gentile G et. al. (2016) Novel Biomarkers for Renal Diseases? None for the Moment (but One).

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14.

Hihara K et. al. (2016) Anti-Phospholipase A2 Receptor (PLA2R) Antibody and Glomerular PLA2R Expression in Japanese Patients with Membranous Nephropathy.

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15.

Li Y et. al. (2016) Single-nucleotide polymorphisms in the PLA2R1 gene are associated with systemic lupus erythematosus and lupus nephritis in a Chinese Han population.

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16.

Radice A et. al. (2016) Clinical usefulness of autoantibodies to M-type phospholipase A2 receptor (PLA2R) for monitoring disease activity in idiopathic membranous nephropathy (IMN).

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17.

Sinico RA et. al. (2016) Immunology of membranous nephropathy: from animal models to humans.

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18.

Wuttke M et. al. (2016) Insights into kidney diseases from genome-wide association studies.

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Update: Sept. 26, 2018